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Association between pharmacokinetics of adalimumab and mucosal healing in patients with inflammatory bowel diseases.
- X. Roblin, H. Marotte, +6 authors S. Paul
- Clinical gastroenterology and hepatology : the…
BACKGROUND & AIMS Little is known about the association between pharmacokinetic features of adalimumab and mucosal healing in patients with inflammatory bowel disease (IBD). METHODS We conducted a… Expand
New insights in mucosal vaccine development.
Mucosal surfaces are the major entrance for infectious pathogens and therefore mucosal immune responses serve as a first line of defence. Most current immunization procedures are obtained by… Expand
COVID-19 may induce Guillain–Barré syndrome
Association Between 6-Thioguanine Nucleotides Levels and Clinical Remission in Inflammatory Disease: A Meta-analysis
Background:A previous meta-analysis suggested that 6-thioguanine nucleotides levels are associated with clinical remission in inflammatory bowel disease. It was criticized because of the relatively… Expand
Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells
This work reports the long-awaited identification of Dectin-1 and Siglec-5 as the M cell co-receptors that mediate the reverse transcytosis of secretory IgA molecules to mount a gut immune response.
Management of cytomegalovirus infection in inflammatory bowel diseases.
- S. Pillet, B. Pozzetto, C. Jarlot, S. Paul, X. Roblin
- Digestive and liver disease : official journal of…
- 1 July 2012
Cytomegalovirus is a deoxyribonucleic acid virus that infects a large part of the human population; after primary infection, it develops a latent state and can be reactivated, notably after a… Expand
Addition of an immunomodulator can reverse antibody formation and loss of response in patients treated with adalimumab
- B. Ungar, U. Kopylov, +11 authors X. Roblin
- Alimentary pharmacology & therapeutics
- 1 January 2017
Anti‐adalimumab antibodies (AAA) are associated with loss of clinical response (LOR). Addition of an immunomodulator has been shown to reverse immunogenicity and regain response with infliximab… Expand
Pharmacokinetics of Adalimumab in Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis
Background:The aim of this meta-analysis was to explore the magnitude of the association between pharmacokinetics of adalimumab and clinical response in patients with inflammatory bowel disease.… Expand
Vaccination recommendations for the adult immunosuppressed patient: A systematic review and comprehensive field synopsis.
BACKGROUND Immunosuppressed patients are at risk of severe viral infections-related complications. National and international vaccination guidelines have been developed to decrease the mortality risk… Expand
Gene-based vaccines and immunotherapeutics
- M. Liu, B. Acres, +4 authors P. Squiban
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 5 October 2004
DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases,… Expand