• Publications
  • Influence
Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement.
TLDR
Complement activation mediated by NS1 leads to local and systemic generation of anaphylatoxins and SC5b-9, which may contribute to the pathogenesis of the vascular leakage that occurs in patients with DHF/DSS. Expand
Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release.
TLDR
It is reported for the first time that vimentin interacts with hnRNPs and dengue NS1, and plays a crucial role in replication and release of d Dengue virus. Expand
Markedly reduced severity of Dengue virus infection in mosquito cell cultures persistently infected with Aedes albopictus densovirus (AalDNV).
TLDR
Questions are raised regarding the potential for persistent infections by unknown viruses to confound experimental results with insect cell lines and reasons for rapid reduction in APC and resistance to superinfection upon serial passage remain unproven. Expand
Renal tubular function in beta-thalassemia.
TLDR
The data confirmed the high frequency of renal abnormalities in beta-thalassemia patients and indicated some degree of proximal tubular dysfunction, and suggested that the damage might be caused by anemia and increased oxidation induced by excess iron deposits. Expand
The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells.
TLDR
Host responses as determined by changes in the cellular proteome of primary human endothelial cells upon infection with dengue virus serotype 2 at a multiplicity of infection (MOI) of 10 for 24 h suggest that various biological processes were triggered in response to d Dengue infection, particularly antiviral IFN and ubiquitin-proteasome pathways. Expand
Renal tubular function in β-thalassemia
TLDR
The data confirmed the high frequency of renal abnormalities in β-thalassemia patients and indicated some degree of proximal tubular dysfunction, and suggested that the damage might be caused by anemia and increased oxidation induced by excess iron deposits. Expand
Rapid detection and identification of dengue viruses by polymerase chain reaction (PCR).
TLDR
A polymerase chain reaction method using sets of newly designed primers for rapid detection and simultaneous identification of dengue virus serotypes was developed and tested, capable of not only detecting the d Dengue virus but also identifying the serotypes of the virus in clinical specimens. Expand
Proteomic analysis of host responses in HepG2 cells during dengue virus infection.
TLDR
Proteomic analysis revealed 17 differentially expressed proteins, which were the key factors involved in transcription and translation processes and may lead to better understanding of the pathogenic mechanisms and host responses to dengue virus infection, and also to the identification of new therapeutic targets for dengu virus infection. Expand
Mosquito cells accommodate balanced, persistent co-infections with a densovirus and Dengue virus.
TLDR
It is suggested that the capacity to support stable, viral co-infections may be a general phenomenon for arthropod cells, and that they may be achieved easily and rapidly by serial passaging of whole cultured cells. Expand
Comparison of penaeid shrimp and insect parvoviruses suggests that viral transfers may occur between two distantly related arthropod groups.
TLDR
The DNA and putative amino acid sequences of representative insect and shrimp parvoviruses (subfamily Densovirinae) were analyzed using computer programs and no significant DNA homology was found except for 77% DNA identity between HPVmon and HPVchin. Expand
...
1
2
3
4
...