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Peptide models for inherited neurodegenerative disorders: conformation and aggregation properties of long polyglutamine peptides with and without interruptions
TLDR
It is suggested that substitution of histidines by glutamines induces a conformational change which results in decreased solubility and increased aggregation and all the polyglutamine peptides with and without interruption(s) adopt a β‐structure and not random coil. Expand
Role of histidine interruption in mitigating the pathological effects of long polyglutamine stretches in SCA1: A molecular approach
TLDR
The relatively lower propensity for aggregation observed in case of histidine interrupted stretches even in the disease range suggests that at a very low concentration, the protein aggregation in normal cells, is possibly not initiated at all or the disease onset is significantly delayed. Expand
Neutralization of alkaline industrial wastewaters using Exiguobacterium sp.
TLDR
Neutralization of highly alkaline wastewater without addition of any external carbon source highlights the potential use of the isolate as an alternative to the conventional acid neutralization method for treatment of alkaline Wastewater. Expand
Inhibition of Protein Aggregation: Supramolecular Assemblies of Arginine Hold the Key
TLDR
It is proposed that molecular clusters of arginine in aqueous solutions display a hydrophobic surface by the alignment of its three methylene groups. Expand
Various drug delivery approaches to the central nervous system
TLDR
This review discusses several strategies adopted to define a rational drug delivery approach to the CNS along with a short description of the strategies implemented by the authors’ group to enhance the analgesic activity, a CNS property, of chimeric peptide of Met-enkephalin and FMRFa (YGGFMKKKFMRFa-YFa). Expand
Interaction studies of novel cell selective antimicrobial peptides with model membranes and E. coli ATCC 11775.
TLDR
Design of six short and potent CAMPs based on a minimalist template of 12 residues H+HHG+HH+HH +HH+NH2 with good antibacterial activity in micro molar concentration range and rapid clearance of Gram-positive and Gram-negative bacterial strains at concentrations higher than MIC are described. Expand
Antimicrobial activity of rationally designed amino terminal modified peptides.
TLDR
Series of short amino terminal modified cationic peptides designed and synthesized exhibit potent antibacterial activity and no hemolytic activity even at high dose level in mammalian erythrocytes was observed. Expand
Effect of varying chain length between P(1) and P(1') position of tripeptidomimics on activity of angiotensin-converting enzyme inhibitors.
TLDR
Results suggest that heterocycles with C(3) chain length are more appropriate for the effective binding of the tripeptidomimics within the active site of ACE. Expand
Usefulness of Organic Acid Produced by Exiguobacterium sp. 12/1 on Neutralization of Alkaline Wastewater
TLDR
Investigation of the role of organic acids produced by Exiguobacterium sp. Expand
Nanoparticle formation from poly(acrylic acid) and oppositely charged peptides.
TLDR
It is proposed that the nanoparticles containing cationic peptides obtained by this methodology can serve as delivery system to enhance the antinociception effect of the chimeric peptide with previously administered doses. Expand
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