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Transport mechanisms in acetylcholine and monoamine storage
- S. Parsons
- Medicine, Chemistry
- FASEB journal : official publication of the…
- 1 December 2000
Sequence‐related vesicular acetylcholine transporter (VAChT) and vesicular monoamine transporter (VMAT) transport neurotransmitter substrates into secretory vesicles. This review seeks to identify… Expand
Acetylcholine transport, storage, and release.
ACh is released from cholinergic nerve terminals under both resting and stimulated conditions. Stimulated release is mediated by exocytosis of synaptic vesicle contents. The structure and function of… Expand
Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels.
- A. Mastrogiacomo, S. Parsons, G. Zampighi, D. Jenden, J. A. Umbach, C. Gundersen
- Biology, Medicine
- 18 February 1994
Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte expression studies suggest that cysteine string proteins are essential subunits or modulators of these channels.… Expand
Changes in the elastic properties of cholinergic synaptic vesicles as measured by atomic force microscopy.
- D. E. Laney, R. A. García, S. Parsons, H. Hansma
- Chemistry, Medicine
- Biophysical journal
- 1 February 1997
Cholinergic synaptic vesicles from Torpedo californica have been probed with the atomic force microscope in aqueous buffers to map and measure their elastic properties. Elastic properties were mapped… Expand
Developmental Changes in the Transmitter Properties of Sympathetic Neurons That Innervate the Periosteum
During the development of sweat gland innervation, interactions with the target tissue induce a change from noradrenergic to cholinergic and peptidergic properties. To determine whether the change in… Expand
Properties of biomolecules measured from atomic force microscope images: a review.
- H. Hansma, K. Kim, +4 authors S. Parsons
- Materials Science, Medicine
- Journal of structural biology
- 1 July 1997
AFM images can be used to obtain quantitative or qualitative information about the properties of biomaterials. Examples presented here are: (1) Persistence length measurements of moving and… Expand
Differential regulation of epaxial and hypaxial muscle development by paraxis.
In vertebrates, skeletal muscle is derived from progenitor cell populations located in the epithelial dermomyotome compartment of the each somite. These cells become committed to the myogenic lineage… Expand
Inhibition of ATP phosphoribosyltransferase by AMP and ADP in the absence and presence of histidine.
Abstract AMP and ADP are linear competitive inhibitors of ATP phosphoribosyltransferase with respect to both substrates in the histidine biosynthetic direction reaction. This apparent contradiction… Expand
Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome
Objective: To identify the genetic basis of a recessive congenital neurologic syndrome characterized by severe hypotonia, arthrogryposis, and respiratory failure. Methods: Identification of the… Expand
The anterior/posterior polarity of somites is disrupted in paraxis-deficient mice.
- J. Johnson, J. Rhee, S. Parsons, D. Brown, E. Olson, A. Rawls
- Biology, Medicine
- Developmental biology
Establishing the anterior/posterior (A/P) boundary of individual somites is important for setting up the segmental body plan of all vertebrates. Resegmentation of adjacent sclerotomes to form the… Expand