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Physical status and expression of HPV genes in cervical cancers.
It was shown that there was not statistically significant association with the different stages, but integrated HPV DNAs were detectable only in the patients with far-advanced stage of cervical cancers, which also means no episomal forms were detected, and RT-PCR seems to be more sensitive than the DNA- PCR method in detecting intact E2 gene. Expand
3'UTR polymorphisms in the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans.
This study showed that genetic variations in the human NRAMP1 gene are associated with susceptibility to smear-positive tuberculosis in Korean patients, which may explain in part why African Americans and Koreans have greater susceptibility to tuberculosis than Caucasians. Expand
Down modulation of IL‐18 expression by human papillomavirus type 16 E6 oncogene via binding to IL‐18
To understand modulation of a novel immune‐related cytokine, interleukin‐18, by human papillomavirus type (HPV) 16 oncogenes, HaCaT, normal keratinocyte cell line, and C‐33A, HPV‐negative cervicalExpand
Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells1
It is suggested that the extracellular HPV 16 E6 and E7 proteins may inhibit IL-18-induced IFN-γ production locally in HPV lesions through inhibition ofIL-18 binding to its α-chain receptor. Expand
alpha(6) Integrin is the main receptor of human papillomavirus type 16 VLP.
The degree of binding of HPV-VLP matched the alpha( 6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) Integrin is the main receptor of HPV type 16. Expand
Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in hepatitis B virus X antigen.
Although the five CTL epitope peptides identified in this study have not been proven to be the naturally processed epitopes in HBV-infected hepatocytes, they could be candidates for peptide-based immunotherapy against HBV infection. Expand
Synthetic peptides of human papillomavirus type 18 E6 harboring HLA-A2.1 motif can induce peptide-specific cytotoxic T-cells from peripheral blood mononuclear cells of healthy donors.
To identify cytotoxic T-cell (CTL) epitopes against human papillomavirus type 18 (HPV 18) E6 protein that might be useful for developing peptide-based vaccine against HPV 18 infection, 18 peptidesExpand
The antibody response to HPV proteins and the genomic state of HPVs in patients with cervical cancer.
Investigation of the relationship between the genomic status of specific HPV genes and their antibody responses to the virus-like particles of HPV-16 L1/L2 proteins and the in vitro translated HPV- 16 E6 and E7 proteins may help to illustrate the mechanism ofHPV-related cervical carcinogenesis and host immune response. Expand
HPV-16-related proteins as the serologic markers in cervical neoplasia.
These data suggest that a considerable number of patients with cervical neoplasia generated positive antibody response to L1/L2 VLPs and in vitro translated E6, E7 proteins of HPV-16, which might be disease-specific markers which could be useful in an adjunctive diagnostic assay and a seroepidemiologic study. Expand
Improvement of gene transfer to cervical cancer cell lines using non-viral agents.
The result support the notion that VLP-PL conjugate may be a promising vector to transfer genetic materials into cancer cells and poloxamer 407 can be used for enhancing the transfection efficiency of V LP-PL Conjugate. Expand