Diagnostic Value of Galectin-3, HBME-1, Cytokeratin 19, High Molecular Weight Cytokeratin, Cyclin D1 and p27kip1 in the Differential Diagnosis of Thyroid Nodules
- Y. J. Park, S. Kwak, Sonjin Park
- Medicine, BiologyJournal of Korean medical science
- 1 August 2007
The distinction between benign and malignant thyroid tumors is critical for the management of patients with thyroid nodules. We applied immunohistochemical staining for galectin-3, HBME-1,…
Generation of PLZF+ CD4+ T cells via MHC class II–dependent thymocyte–thymocyte interaction is a physiological process in humans
- You Jeong Lee, Y. Jeon, S. Park
- Biology, MedicineJournal of Experimental Medicine
- 18 January 2010
It is determined that a substantial number of fetal thymocytes and splenocytes express PLZF and acquire innate characteristics during their development in humans, defining a novel human CD4+ T cell subset that develops via an MHC class II–dependent T–T interaction.
NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor β1 production
- Hye Young Kim, Hyun Jung Kim, D. Chung
- Biology, MedicineJournal of Experimental Medicine
- 3 January 2005
NKT cells producing IL-4 and IFN-γ play a role in immune complex–induced joint inflammation by regulating TGF-β1, and in vitro assay demonstrated that interleukin (IL)-4 and interferon (IFN)-γ were involved in suppressing TGF -β1 production in joint cells.
S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid
- H. Min, G. Choe, S. Y. Park
- MedicineModern Pathology
- 1 June 2008
S 100A4 expression in papillary microcarcinomas may indicate the presence of nodal metastasis, and S100A4 immunohistochemistry may be valuable for predicting metastatic potential in papilla microcARCinomas.
A Splice Variant of CD99 Increases Motility and MMP-9 Expression of Human Breast Cancer Cells through the AKT-, ERK-, and JNK-dependent AP-1 Activation Signaling Pathways*
- Hee-Jung Byun, In-Kee Hong, Hansoo Lee
- Biology, ChemistryJournal of Biological Chemistry
- 17 November 2006
Results suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1-mediated gene expression through the Akt-dependent ERK and JNK signaling pathways.
CD99 Regulates the Transport of MHC Class I Molecules from the Golgi Complex to the Cell Surface1
The results suggest that CD99 may be associated with the post-Golgi trafficking machinery by regulating the transport to the plasma membrane rather than the endocytosis of surface MHC class I molecules, providing a novel mechanism of M HC class I down-regulation for immune escape.
Analysis of differential BRAF(V600E) mutational status in multifocal papillary thyroid carcinoma: evidence of independent clonal origin in distinct tumor foci.
- S. Y. Park, Y. J. Park, B. Cho
- Medicine, BiologyCancer
- 15 October 2006
At least 39.3% of the multifocal papillary cancers in the Korean population that were examined could be attributed to independently arising papillary cancer rather than to intrathyroidal spread of single cancers.
MHC Class II-Restricted Interaction between Thymocytes Plays an Essential Role in the Production of Innate CD8+ T Cells
- H. Min, You Jeong Lee, S. Park
- Biology, MedicineJournal of Immunology
- 15 May 2011
It is reported that the thymic T–T interaction is essential for the conversion of CD8+ T cells into innate phenotype in the physiological condition, and suggests that PLZF+ T-T CD4-T cells in combination with Eomes+ CD8- T cells might actively participate in the innate immune response against various pathogens, particularly in human perinatal period.
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