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Diagnostic Value of Galectin-3, HBME-1, Cytokeratin 19, High Molecular Weight Cytokeratin, Cyclin D1 and p27kip1 in the Differential Diagnosis of Thyroid Nodules
The distinction between benign and malignant thyroid tumors is critical for the management of patients with thyroid nodules. We applied immunohistochemical staining for galectin-3, HBME-1,
A Splice Variant of CD99 Increases Motility and MMP-9 Expression of Human Breast Cancer Cells through the AKT-, ERK-, and JNK-dependent AP-1 Activation Signaling Pathways*
TLDR
Results suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1-mediated gene expression through the Akt-dependent ERK and JNK signaling pathways.
NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor β1 production
TLDR
NKT cells producing IL-4 and IFN-γ play a role in immune complex–induced joint inflammation by regulating TGF-β1, and in vitro assay demonstrated that interleukin (IL)-4 and interferon (IFN)-γ were involved in suppressing TGF -β1 production in joint cells.
S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid
TLDR
S 100A4 expression in papillary microcarcinomas may indicate the presence of nodal metastasis, and S100A4 immunohistochemistry may be valuable for predicting metastatic potential in papilla microcARCinomas.
Generation of PLZF+ CD4+ T cells via MHC class II–dependent thymocyte–thymocyte interaction is a physiological process in humans
TLDR
It is determined that a substantial number of fetal thymocytes and splenocytes express PLZF and acquire innate characteristics during their development in humans, defining a novel human CD4+ T cell subset that develops via an MHC class II–dependent T–T interaction.
Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs.
TLDR
Observations support the inference that the evolutionary conserved gene, CD99L2, originated from a common ancestor gene of CD99, and its high conservation among species implies at least some essential function.
Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region.
TLDR
It is suggested that CD99 belongs to the ancient PAR genes, and that the rapid interspecies divergence of its present sequence and map position is due to a high recombination frequency and the occurrence of chromosomal translocation, supporting the addition-attrition hypothesis for PAR evolution.
Analysis of differential BRAF(V600E) mutational status in multifocal papillary thyroid carcinoma: evidence of independent clonal origin in distinct tumor foci.
TLDR
At least 39.3% of the multifocal papillary cancers in the Korean population that were examined could be attributed to independently arising papillary cancer rather than to intrathyroidal spread of single cancers.
ILK (β1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing’s sarcoma and primitive neuroectodermal tumour
TLDR
The findings support the notion that ES is a tumour that is closely related to PNET and that both originate from the neuroectoderm and are useful for the positive identification of ES and PNET in formalin-fixed, paraffin-embedded tissue sections.
MHC Class II-Restricted Interaction between Thymocytes Plays an Essential Role in the Production of Innate CD8+ T Cells
TLDR
It is reported that the thymic T–T interaction is essential for the conversion of CD8+ T cells into innate phenotype in the physiological condition, and suggests that PLZF+ T-T CD4-T cells in combination with Eomes+ CD8- T cells might actively participate in the innate immune response against various pathogens, particularly in human perinatal period.
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