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Frequencies of VKORC1 -1639 G>A, CYP2C9*2 and CYP2C9*3 genetic variants in the Northern Indian population.
TLDR
The VKORC1 -1639 G>A allele is present at moderately high frequency in the Northern Indian population and the frequencies of CYP2C9*2 and CYP9*3 alleles are also found to be different from other populations.
Association study of inflammatory genes with rheumatic heart disease in North Indian population: A multi-analytical approach.
TLDR
Important role of TGF-β1 869T/C [rs1982073] in RHD susceptibility is revealed, using multi-analytical approaches, to discover high-order gene-gene interactions in studiedgenes involved in R HD susceptibility.
Therapeutic Dosing of Acenocoumarol: Proposal of a Population Specific Pharmacogenetic Dosing Algorithm and Its Validation in North Indians
TLDR
An efficient north India specific pharmacogenetic acenocoumarol dosing algorithm is proposed which might become a baseline for personalised medicine approach for treatment of patients in future.
Influence of protein tyrosine phosphatase gene (PTPN22) polymorphisms on rheumatic heart disease susceptibility in North Indian population.
TLDR
PTPN22 haplotype may modulate the risk to RHD in North Indians, and turned out to be a low risk factor for RHD (P = 0.0042) predisposition in females and adult patients.
Association of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease in Indian population and meta-analysis
TLDR
ACE ID and DD genotypes are associated with an increased risk of RHD, particularly CVL, which suggests that the ACE I/D gene polymorphism may play an important role in the pathogenesis of R HD.
Utility of Thromboelastography versus Routine Coagulation Tests for Assessment of Hypocoagulable State in Patients Undergoing Cardiac Bypass Surgery
TLDR
Evaluated usefulness of Thromboelastography (TEG) and routine coagulation tests (RCT) in assessing hemostatic changes and predicting postoperative bleeding in patients undergoing cardiac surgery with cardiopulmonary bypass found TEG parameters R time and MA in postoperative samples were the only parameters that predicted bleeders with fair accuracy.
A new classification of inferior vena cava thrombus in renal cell carcinoma could define the need for cardiopulmonary or venovenous bypass
TLDR
A simple three-level classification based on the need for clamping hepatoduodenal ligament and venovenous or cardiopulmonary bypass is illustrated for renal vein thrombus, which should not be categorized as level I throm bus.
CYP4F2 1347 G>A & GGCX 12970 C>G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant
Background & objectives: CYP4F2 and γ-glutamyl carboxylase (GGCX) have small but significant roles in the maintenance dose of coumarinic oral anticoagulants (COAs). CYP4F2 1347 G>A and GGCX 12970 C>G
Pericardial Monocusp for Pulmonary Valve Reconstruction: A New Technique
TLDR
This technique for creating an autologous pericardial monocusp valve is an inexpensive, simple, and reliable procedure that effectively reduces pulmonary insufficiency at the 1-year follow-up.
The impact of VKORC1-1639 G>A polymorphism on the maintenance dose of oral anticoagulants for thromboembolic prophylaxis in North India: A pilot study
TLDR
The VKORC1-1639 G>A status can be indicative of establishing the therapeutic dose of oral anticoagulants in Indian patients, and the minor allele frequency in the study population was found to be 22%.
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