• Publications
  • Influence
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
TLDR
Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation. Expand
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
TLDR
It is demonstrated that the nutrient-responsive adenosine monophosphate–activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1), which acts as chemical energy sensors in mammals. Expand
Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog.
TLDR
The toc1 mutation causes shortened circadian rhythms in light-grown Arabidopsis plants and it is shown that TOC1 controls photoperiodic flowering response through clock function. Expand
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
TLDR
Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. Expand
Harmonics of Circadian Gene Transcription in Mammals
TLDR
These studies illustrate the importance of time sampling with respect to multiple testing, suggest caution in use of autonomous cellular models to study clock output, and demonstrate the existence of harmonics of circadian gene expression in the mouse. Expand
A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
TLDR
Results suggest that opposing activities of the orphan nuclear receptors Rora and Rev-erb alpha, which represses Bmal1 expression, are important in the maintenance of circadian clock function. Expand
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression
TLDR
It is shown that both temporal pattern of food intake and the circadian clock drive rhythmic transcription, thereby highlighting temporal regulation of hepatic transcription as an emergent property of the circadian system. Expand
Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting
TLDR
These mice display severely attenuated phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in circadian photoentrainment in mammals. Expand
ELF3 Modulates Resetting of the Circadian Clock in Arabidopsis
TLDR
It is shown conclusively that normal circadian function occurs with no alteration of period length in Elf3 mutants in dark conditions and that the light-dependent arrhythmia observed in elf3 mutants is pleiotropic on multiple outputs normally expressed at different times of day. Expand
Circadian rhythms from flies to human
TLDR
The existence of a circadian clock in humans had been postulated for decades, but an understanding of the molecular mechanisms has required the full complement of research tools, and researchers turned to genetically tractable model organisms such as Drosophila. Expand
...
1
2
3
4
5
...