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Glycerol monolaurate prevents mucosal SIV transmission
TLDR
G glycerol monolaurate—a widely used antimicrobial compound with inhibitory activity against the production of MIP-3α and other proinflammatory cytokines—can inhibit mucosal signalling and the innate and inflammatory response to HIV-1 and SIV in vitro, and in vivo it can protect rhesus macaques from acute infection despite repeated intra-vaginal exposure to high doses of SIV.
Identification of a Gene Expression Signature Associated with Recurrent Disease in Squamous Cell Carcinoma of the Head and Neck
TLDR
Of particular interest was the association of a gene expression signature enriched for genes involved in tumor invasion and metastasis with patients experiencing locally recurrent disease, suggesting that modulation of tumor-specific immune responses may play a role in local treatment failure in HNSCC.
Salivary Duct Carcinoma
TLDR
The most characteristic features of salivary duct carcinoma by fine needle aspiration appear to be flat sheets with a cribriform pattern and tumor cells in a necrotic background with pleomorphic, eccentric nuclei and granular cytoplasm.
Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Series of 24 Patients
TLDR
It is suggested that PASH is primarily a diagnosis of premenopausal and perimenopausal women and a hormonal basis for its development due to the positive staining for hormonal receptors is supported.
HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features
TLDR
HMSC is a distinct sinonasal neoplasm characterized by myoepithelial differentiation, frequent surface epithelial involvement, and the presence of high-risk HPV (especially type 33), which classically exhibits a cribriforming pattern that closely resembles adenoid cystic carcinoma.
Endobronchial ultrasound-guided transbronchial fine-needle aspiration: the University of Minnesota experience, with emphasis on usefulness, adequacy assessment, and diagnostic difficulties.
TLDR
It is found EBUS-TBNA to have a high specificity (100%) and good sensitivity (86%) in this institution, in which a cytopathologist is available on-site to ensure sample adequacy.
Disaggregation and invasion of ovarian carcinoma ascites spheroids
TLDR
The results suggest that systematic studies of the ascites cellular content are necessary to understand the biology of ovarian carcinoma, and in vitro assays using ascites spheroids that imitate the spread of ovarian cancer in vivo are suggested.
Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker.
TLDR
R reverse transcriptase-polymerase chain reaction and quantitative RT-PCR validated the overexpression of nectin 4 messenger RNA in ovarian cancer compared with normal ovarian cell lines and tissues and suggested that nECTin 4 may serve as a potential biomarker that helps discriminate benign gynecologic diseases from ovarian cancer in a panel with CA125.
Glycerol Monolaurate Does Not Alter Rhesus Macaque (Macaca mulatta) Vaginal Lactobacilli and Is Safe for Chronic Use
TLDR
GML was tested both in vitro for its effects on vaginal flora lactobacilli and in vivo as a 5% gel administered vaginally to monkeys, suggesting that GML is safe for chronic use in monkeys when applied vaginally; it does not alter either mucosal microflora or integrity.
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