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Stat3 and c-Myc Genome-Wide Promoter Occupancy in Embryonic Stem Cells
Investigation of genome-wide chromatin immunoprecipitation and microarray analysis reveals transcriptional targets of two key pluripotency-related genes in ES cells – Stat3 and c-Myc, thus providing further insight into the ES cell transcriptional network.
Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance.
Through genome-wide mapping and global expression analysis of five TF target genes, the data provide a comprehensive analysis of transcriptional networks that regulate TS cell self-renewal.
Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase*
- J. Cottom, L. M. Salvador, M. Hunzicker-Dunn
- Biology, Computer ScienceJournal of Biological Chemistry
- 28 February 2003
The results suggest that FSH stimulates ERK activity in immature granulosa cells by relieving an inhibition imposed by a 100-kDa phosphotyrosine phosphatase.
Annual changes in serum sex steroids in male and female black (Ursus americanus) and polar (Ursus maritimus) bears.
It is found that serum sex steroids measured in black and polar bears change independent of torpor, suggesting that photoperiod may be a more important regulator of serum steroid levels and reproduction than metabolic condition.
SWI/SNF‐Brg1 Regulates Self‐Renewal and Occupies Core Pluripotency‐Related Genes in Embryonic Stem Cells
It is reported that Brg1 is required for ES cell self‐renewal and pluripotency and co‐occupied a subset of Oct4, Sox2, Nanog, and PcG protein target genes.
HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells
It is found that HDAC1 occupies mainly active genes, including important regulators of ES and TS cells self-renewal, including the pluripotency regulators Oct4, Nanog and Kfl4.
Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats.
Oocytes that were ovulated after PDE4 inhibition could be fertilized in vitro at a rate similar to that of oocytes from hCG-induced ovulation, indicating that small molecule PDE 4 inhibitors may be orally active alternatives to hCG as part of a fertility treatment regimen.
Tumor Necrosis Factor-α Regulates Inflammatory and Mesenchymal Responses via Mitogen-Activated Protein Kinase Kinase, p38, and Nuclear Factor κB in Human Endometriotic Epithelial Cells
It is demonstrated that interruption of TNF-α-induced signaling pathways in human endometriotic epithelial cells results in decreased expression and secretion of biomarkers for inflammation, EMT, and disease progression.
Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing.
- Richard M. Thomas, Cheryl A. Nechamen, J. Mazurkiewicz, M. Muda, S. Palmer, J. Dias
- Biology, ChemistryEndocrinology
- 1 May 2007
Results provide the first evidence for oligomers of full-length F SHR in situ and for C-terminal proteolytic processing of FSHR and that both events take place during biosynthesis, which may explain how heterozygous mutations in the FSHr gene that affect receptor trafficking may be ameliorated by oligomer formation.
Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process.
- Zhilin Liu, D. D. de Matos, H. Fan, M. Shimada, S. Palmer, J. Richards
- 1 July 2009
Data indicate that IL-6 alone can act as a potent autocrine regulator of ovarian cumulus cell function, COC expansion, and oocyte competence.