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Neurotensin receptor expression in prostate cancer cell line and growth effect of NT at physiological concentrations
- L. Seethalakshmi, S. P. Mitra, P. Dobner, M. Menon, R. Carraway
- Biology, Medicine
- The Prostate
- 15 May 1997
Neurotensin (NT), a neuroendocrine peptide, exerts trophic effects in vivo and stimulates growth of some tumor cells in vitro. Androgen‐sensitive prostate cells derived from lymph node carcinoma of… Expand
Posttranslational Processing of the Neurotensin/Neuromedin‐N Precursor
- R. Carraway, S. P. Mitra, G. Spaulding
- Medicine, Biology
- Annals of the New York Academy of Sciences
- 1 October 1992
Posttranslational processing can be a key regulatory step in determining the quantity and types of products derived from precursors to biologically active peptides. 1-4 Although the “limited… Expand
Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells.
Since neurotensin is often co-stored with catecholamines and since it can excite the release of dopamine and norepinephrine, responses to this peptide might depend upon the activity of… Expand
Binding and biologic activity of neurotensin in guinea pig ileum
Experiments were performed to relate receptor binding to biologic activity for the contractile effect of neurotensin (NT) in guinea pig ileum. The contractile response was examined on pieces of ileum… Expand
Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+-dependent adenylyl cyclase(s)
A human prostate cancer cell line (PC3) with abundant neurotensin (NT) receptors was used to demonstrate that NT potentiated 3',5'-cyclic adenosine monophate (cAMP) accumulation in response to a… Expand
High Affinity Binding of 125I-Neurotensin to Dispersed Cells from Chicken Liver and Brain
Dispersed cells from chicken brain and liver were found to possess cell surface binding sites for 125I-neurotensin (125I-NT). Scatchard analyses indicated the presence of high affinity (K4, 25-80 pM)… Expand
Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s).
- R. Carraway, S. P. Mitra, D. Cochrane
- Chemistry, Medicine
- The Journal of biological chemistry
- 5 May 1987
Using a radioimmunoassay toward the COOH-terminal region of neurotensin, an immunoreactive and biologically active neurotensin-related peptide (NRP) has been isolated from pepsin-treated fractions of… Expand
The use of radioimmunoassay to compare the tissue and subcellular distributions of neurotensin and neuromedin N in the cat.
A RIA for neuromedin N (NMN) was developed using 125I-labeled NMN and rabbit antisera raised against a synthetic NMN coupled to NH2-enriched putrescine-thyroglobulin. One of the antisera (TG-B),… Expand
Differential processing of neurotensin/neuromedin N precursor(s) in canine brain and intestine.
By using a radioimmunoassay for neuromedin N (NMN), a hexapeptide in the neurotensin (NT) family, extracts of canine small intestine were found to contain primarily (greater than 75%) large molecular… Expand
Xenopsin-related peptide generated in avian gastric extracts
Two avian counterparts to amphibian xenopsin have been identified as H-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-OH (XP-2) and its partial sequence H-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-OH (XP-1) isolated from… Expand