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Regulation of the synthesis and release of slow-reacting substance of anaphylaxis from sensitized monkey lung.
A potential role for LTD in regulating the amount of SRS-A released from monkey lung is demonstrated and significant inhibition was observed at 150 ng/ml, which, in part, may have been produced by metabolism to leukotriene D4.
Immunologic mediator release from rhesus and cynomolgus monkey lung.
It is demonstrated that the cynomolgus monkey can be used as a substitute for the rhesus monkey in immediate-type hypersensitivity reactions and quantitation of this endogenous reaginic reactivity suggested the presence of a high incidence of “allergic” animals among the monkey population.
Effect of histamine H2 receptor agonists and antagonists on pulmonary histamine release and smooth muscle
Cimetidine, an H2 receptor antagonist, moderately enhanced immunologically-induced histamine release from rhesus monkey, but not rat, lung and functional histamine H2 receptors mediating relaxation seem to be present in rhesu monkey respiratory smooth muscle.
Immunologic histamine release in vitro from the heart and lung of the cynomolgus monkey.
It is demonstrated that ventricular histamine may be immunologically released and that this release process can be pharmacologically inhibited in a manner similar to that of pulmonary tissue.