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Structure of the forkhead domain of FOXP2 bound to DNA.
FOXP (FOXP1-4) is a newly defined subfamily of the forkhead box (FOX) transcription factors. A mutation in the FOXP2 forkhead domain cosegregates with a severe speech disorder, whereas severalExpand
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Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzymeExpand
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Selection on human genes as revealed by comparisons to chimpanzee cDNA.
To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction withExpand
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Comparative primate genomics.
  • W. Enard, S. Pāābo
  • Biology, Medicine
  • Annual review of genomics and human genetics
  • 26 August 2004
With the completion of the human genome sequence and the advent of technologies to study functional aspects of genomes, molecular comparisons between humans and other primates have gained momentum.Expand
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Mammoth DNA sequences
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Transcriptome analysis of male–female differences in prefrontal cortical development
Human neuropsychiatric disorders that involve the prefrontal cortex show gender differences in age of onset, prevalence and symptomatology. Gender dimorphisms in human-brain development may includeExpand
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Amino acid racemization in amber-entombed insects: implications for DNA preservation.
DNA depurination and amino acid racemization take place at similar rates in aqueous solution at neutral pH. This relationship suggests that amino acid racemization may be useful in accessing theExpand
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Ancient DNA: Extraction, characterization, molecular cloning, and enzymatic amplifi'cation (oxidative damage/electron microscopy/Alu sequences/mitochondrial DNA/polymerase chain reaction)
Several chemical and enzymatic properties were examined in the DNA extracted from dry remains of soft tissues that vary in age from 4 to 13,000 years and represent four species, including two extinctExpand
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Of bears, conservation genetics, and the value of time travel.
  • S. Pāābo
  • Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000
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Evolution Dynamics of mitochondrial DNA evolution in animals : Amplification and sequencing with conserved primers ( cytochrome b / 12 S ribosomal DNA / control region / evolutionary genetics /
With a standard set of primers directed toward conserved regions, we have used the polymerase chain reaction to amplify homologous segments ofmtDNA from more than 100 animal species, includingExpand
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