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Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class.
Some novel 1-methyl-4-(2-substitutedphenyl-1H-benzimidazol-1-yl)acetyl)thiosemicarbazides synthesized and tested for antioxidant properties by using various in vitro systems found to be a good scavenger of DPPH radical when compared to BHT. Expand
Triterpene saponins from Cyclamen trocopteranthum.
Two new triterpene saponins were isolated from the tubers of Cyclamen trocopteranthum and showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells. Expand
The molecular structure of the title compound, C(11)H(9)NOS, has three planar moieties, two of which are rings, namely the hydroxyphenyl and the thiophene, with an angle of 20.76 (10) degrees betweenExpand
Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents.
Three new compounds synthesized from treating the 5-substituted 1H-indole-2,3-diones with 2-aminothiophenol in ethanol showed potent scavenging activities against DPPH* and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS*(+)) radicals, reducing powers, and strong inhibitory capacity on lipid peroxidation. Expand
Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities.
Most of the compounds exhibited both anticonvulsant and antimicrobial activities; the O-alkyl substituted compounds (2, 3, 4 and 5) were found to be more active than theO-arylalkyl substitution compounds in both screening paradigms. Expand
Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives.
The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction. Expand
3-(2-furyl)-6-(4-methylphenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine and its 6-phenyl analogue.
In the title compounds, C15H12N4OS, (I), and C14H10N4OS, (II), the thia­diazine ring adopts a skew-boat conformation, while the triazole and furyl rings are essentially planar. The phenyl group isExpand
Synthesis and antimicrobial evaluation of some new substituted purine derivatives.
Compound 22 carrying 4-chlorobenzylamino group at the 6-position of the purine moiety exhibited comparable antibacterial activity with that of the standard ciprofloxacin against both of the drug-resistant bacteria (MRSA, standard and clinical isolate). Expand
Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.
The compound 36 had better cytotoxic activities than the nucleobase 5-FU and nucleosides fludarabine, cladribine, and pentostatine on Huh7 cells and was later identified as senescence associated cell death by SA-β-Gal assay. Expand
Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide.
In the molecule of the title compound, C26H21N3O5S, a new type of sulfonamide derivative with potential antibacterial activity, the flavone moiety is almost planar. The isoxazole and aminophenylExpand