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Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.
TLDR
This study provides for the first time a biochemical proof of principle for metabolic treatment in glutaric aciduria type I and suggests that further optimization of treatment could be achieved by exploitation of competition between L-lysine and L-arginine at physiological barriers and enhancement of peroxisomal L- Elysine oxidation and glutARic acid breakdown. Expand
Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal
TLDR
MxB uses residues 11RRR13 to bind to the HIV-1 core during infection and that these residues are required for the ability of MxB to block HIV-2 infection and a nuclear localization signal is found that is not required for restriction. Expand
Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection
TLDR
It is reported that the dynein adapter protein bicaudal D2 (BICD2) is able to interact with HIV-1 viral cores in target cells and can bind in vitro-assembled capsid tubes through its CC3 domain. Expand
SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV
TLDR
It is shown that SUN2 overexpression blocks the infection of certain strains of HIV before nuclear entry and highlights novel links between nuclear shape and viral infection. Expand
Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.
TLDR
Using the "fate of the capsid" assay, it is demonstrated that the viral core of S5-restricted HIV-1 does not reach the cytoplasm of target cells, suggesting a block in the delivery of the core to the cy toplasm. Expand
Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
TLDR
New crystal structures of hexameric HIV-1 capsid are solved in complex with a Nup153-derived peptide containing a phenylalanine-glycine repeat (FG repeat), which is used to guide structure-based mutagenesis of the capsid-binding interface. Expand
Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the
TLDR
Results indicate a low but specific efflux transport for GA, 3-OH-GA, and MMA across pBCEC, an in vitro model of the BBB, via OAT1 and OAT3 but not across hCPEC, the in vitro models of the blood-brain barrier and the choroid plexus. Expand
BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid
TLDR
This work demonstrates that BI-2 destabilizes the HIV-1 core during infection, and prevents the binding of the cellular factor CPSF6 to the HIV -1 core. Expand
Contribution of MxB Oligomerization to HIV-1 Capsid Binding and Restriction
TLDR
It is shown that oligomerization is required for the ability of MxB to bind to the HIV-1 core and block HIV- 1 infection. Expand
HIV-1 capsid is involved in post-nuclear entry steps
TLDR
It is reported that C-A1 inhibits HIV-1 integration in a capsid-dependent way and results indicate that capsid is involved in post-nuclear entry steps preceding integration. Expand
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