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Structure of the Chemokine Receptor CXCR1 in Phospholipid Bilayers
CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumour growth.Expand
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Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy
The structures of functional peptides corresponding to the predicted channel-lining M2 segments of the nicotinic acetylcholine receptor (AChR) and of a glutamate receptor of the NMDA subtype (NMDAR)Expand
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Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1.
The three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer samples. Vpu(2-30+) is aExpand
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A solid-state NMR index of helical membrane protein structure and topology.
The secondary structure and topology of membrane proteins can be described by inspection of two-dimensional (1)H-(15)N dipolar coupling/(15)N chemical shift polarization inversion spin exchange atExpand
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Simultaneous assignment and structure determination of a membrane protein from NMR orientational restraints
  • F. Marassi, S. Opella
  • Medicine, Chemistry
  • Protein science : a publication of the Protein…
  • 1 March 2003
A solid‐state NMR approach for simultaneous resonance assignment and three‐dimensional structure determination of a membrane protein in lipid bilayers is described. The approach is based on theExpand
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HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions*
  • Mark Skasko, Yan Wang, +6 authors J. Guatelli
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 9 November 2011
Background: HIV-1 Vpu counteracts the cellular antiviral factor BST-2 via an interaction that maps to the transmembrane domains of each protein. Results: This interaction is detectable by NMRExpand
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Selective averaging for high-resolution solid-state NMR spectroscopy of aligned samples.
Solid-state NMR experiments benefit from being performed at high fields, and this is essential in order to obtain spectra with the resolution and sensitivity required for applications to proteinExpand
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Structure of the coat protein in Pf1 bacteriophage determined by solid-state NMR spectroscopy.
The atomic resolution structure of Pf1 coat protein determined by solid-state NMR spectroscopy of magnetically aligned filamentous bacteriophage particles in solution is compared to the structuresExpand
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Tilt angle of a trans-membrane helix is determined by hydrophobic mismatch.
In order to investigate the compensation mechanism of a trans-membrane helix in response to hydrophobic mismatch, the tilt and rotation angles of the trans-membrane helix of Vpu aligned in lipidExpand
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