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Loss of a conserved 7‐methylguanosine modification in 16S rRNA confers low‐level streptomycin resistance in bacteria
TLDR
GidB is identified as a new streptomycin‐resistance locus and a resistance mechanism that is mediated by loss of a conserved m7G modification in 16S rRNA is uncovered, which may provide a basis for developing strategies to suppress pathogenic bacteria, including M. tuberculosis. Expand
Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites
TLDR
IFN gamma synergistically enhanced TNFalpha-induced IL-8 production in a human gastric cancer cell line through synergistic activation of transcription factors without up-regulating TNF alpha receptor is indicated. Expand
The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions
TLDR
It is shown that T cell receptor–induced interleukin (IL)-4 secretion by SLAM−/− CD4+ cells is down-regulated, whereas interferon γ production by CD4+, and that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses. Expand
Enhanced Expression of S-Adenosylmethionine Synthetase Causes Overproduction of Actinorhodin in Streptomyces coelicolor A3(2)
TLDR
Findings implicate the significant involvement of intracellular SAM in initiating the onset of secondary metabolism in Streptomyces coelicolor A3(2) mutant (KO-179). Expand
Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.
TLDR
Collectively, dexamethasone interfered with the binding of the most essential transcription factor, NF-kappa B, to its cognate cis-element, thereby suppressing the transcription of IL-8 gene. Expand
Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
TLDR
Results indicate that the onset and extent of secondary metabolism in Streptomyces spp. Expand
An essential GTP‐binding protein functions as a regulator for differentiation in Streptomyces coelicolor
TLDR
Western analysis revealed that expression of obg is regulated in a growth phase‐dependent manner, indicating a sharp decrease just after onset of aerial mycelium development or at the end of vegetative growth. Expand
Ribosome engineering and secondary metabolite production.
TLDR
This chapter outlines ribosome engineering and its applicability, especially focusing on strain improvement for antibiotic overproduction in Streptomyces and Bacillus and for enhancement of tolerance to organic chemicals in Pseudomonas. Expand
Acquisition of Certain Streptomycin-Resistant (str) Mutations Enhances Antibiotic Production in Bacteria
TLDR
It is found that the acquisition of certain streptomycin-resistant (str) mutations enables cells to overproduce antibiotics, demonstrating an increase in productivity 5- to 50-fold greater than that of wild-type strains. Expand
Bacilysocin, a Novel Phospholipid Antibiotic Produced by Bacillus subtilis 168
TLDR
A novel phospholipid antibiotic is found which accumulates within (or associates with) the cells of Bacillus subtilis 168 and the structure was determined by nuclear magnetic resonance and mass spectrometry analyses, which demonstrated antimicrobial activity. Expand
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