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Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa
TLDR
To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD- oprJ, and MexXY-OPRM, a series of isogenic mutants were constructed, each constitutively overproduced one of the three efflux system and lacked the other two. Expand
Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa
TLDR
The results suggest that MexXY induced by these agents is functionally associated with spontaneously expressed OprM and contributes to the intrinsic resistance to these agents. Expand
Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa
TLDR
Three types of multiple-drug-resistant mutants which were phenotypically similar to previously described nalB, nfxB, and nfxC mutants were isolated from Pseudomonas aeruginosa PAO1 and two clinical isolates, suggesting that at least three different outer membrane proteins, OprM, OPRJ, and OprN, are associated with multiple drug resistance in P. aerug inosa. Expand
Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa
  • N. Masuda, S. Ohya
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 September 1992
TLDR
The data suggest that overproduction of OprM is associated with cross-resistance to meropenem, cephems, and quinolones in P. aeruginosa. Expand
Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa
TLDR
Results suggest that there are at least two nfxB mutations that show different phenotypes and that production of OprJ is associated with changes in susceptibilities of NfxB mutants. Expand
Interplay between Chromosomal β-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to β-Lactams inPseudomonas aeruginosa
TLDR
The intrinsic resistance of P. aeruginosa to most of the β-lactams is due to the interplay of both factors, and the role of chromosomal β- lactamase and the MexAB-OprM efflux system is investigated. Expand
Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa.
TLDR
The intrinsic resistance of P. aeruginosa to most of the beta-lactams is due to the interplay of both factors, and the role of chromosomal beta- lactamase and the MexAB-OprM efflux system is investigated. Expand
Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus
In vitro and in vivo antibacterial activities of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant (MR) strains of Staphylococcus aureus wereExpand
The Contributions of Reactive Oxygen Intermediates and Reactive Nitrogen Intermediates to Listericidal Mechanisms Differ in Macrophages Activated Pre- and Postinfection
TLDR
The contributions of ROI and RNI to listericidal mechanisms of macrophages were different betweenMacrophages activated at pre- and postinfection stages, and a significant level of enhanced killing was observed. Expand
In Vitro and In Vivo Antibacterial Activities of CS-023 (RO4908463), a Novel Parenteral Carbapenem
TLDR
Results suggest that CS-023 has potential for the treatment of nosocomial bacterial infections by gram-positive and -negative pathogens, including MRSA and P. aeruginosa. Expand
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