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Synthesis and antiinflammatory and hypnotic activity of 5-alkoxy-3-(N-substituted carbamoyl)-1-phenylpyrazoles.
5-Alkoxy-3-(N-substituted carbamoly)-1-phenylpyrazoles were prepared and tested for antiinflammatory and hypnotic activity. Four compounds showed antiinflammatory activity and three possessedExpand
Synthesis of asymmetric 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates with vasodilating and antihypertensive activities.
Asymmetric 4-aryl-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridinedicarboxylates with a 2-ethylenedioxypropyl, 2-oxopropyl, or cyclopropylmethyl group as the ester moiety and related derivatives wereExpand
Synthesis of 2-aryl-2,3-dihydro-3-piperazinylmethyl-1,5-benzothiazepin-4(5H)-ones and related compounds
A series of trans- (12) and cis-2-aryl-2, 3-dihydro-3-piperazinylmethy-1, 5-benzothiazepin-4(5H)-ones(13) and related compounds were synthesized. Diethyl arylmethylenemalonates (3) were heated withExpand
Synthesis and hypoglycemic activity of 7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives and related compounds.
Synthesis and structure-activity relationships of new (5R,8R,10R)-ergoline derivatives with antihypertensive or dopaminergic activity.
A series of new (5R,8R,10R)-ergoline derivatives was synthesized, and their antihypertensive and dopaminergic activities were tested in conscious spontaneously hypertensive rats and in rats withExpand
Synthesis of a new potent anti-ulcer and gastric secretory inhibiting agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5H)-one hydrochloride (BTM-1086), and
(-)-cis-2, 3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1, 5-benzothiazepin-4 (5H)-one hydrochloride (BTM-1086) and its analogues, which possessed potent anti-ulcer and gastric secretoryExpand
A MODIFIED MANNICH REACTION USING 1, 3-DIOXOLANE
Mannich reaction of ketones using 1, 3-dioxolane instead of formaldehyde, paraformaldehyde, or 1, 3, 5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions theExpand
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