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Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry.
New bioanalytical methods have been developed for the determination of imidafenacin (KRP-197/ONO-8025, IM), a novel antimuscarinic drug developed for the treatment of overactive bladder, and itsExpand
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Dihydroetorphine: a potent analgesic: pharmacology, toxicology, pharmacokinetics, and clinical effects.
Dihydroetorphine (DHE) is one of the strongest analgesic opioid alkaloids known; it is 1000 to 12000 times more potent than morphine. Several in vitro and in vivo studies have shown that DHE is aExpand
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Water-Diluted Local Anesthetic for Trigger-Point Injection in Chronic Myofascial Pain Syndrome: Evaluation of Types of Local Anesthetic and Concentrations in Water
Background and Objectives We have recently demonstrated that a mixture of 1% lidocaine with water in a 1:3 ratio has less injection pain and is more effective than unaltered 1% lidocaine in treatingExpand
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Development and validation of bioanalytical methods for Imidafenacin (KRP-197/ONO-8025) and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
Imidafenacin (KRP-197/ONO-8025, IM), 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide, is a new antimuscarinic agent currently under application for the indication of treatment of overactiveExpand
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Nafamostat mesilate, a kallikrein inhibitor, prevents pain on injection with propofol.
We have examined the preventative effect of nafamostat mesilate, a kallikrein inhibitor, on pain on injection with propofol in a randomized, double-blind study. A control group (n = 110) and aExpand
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Absorption, Metabolism, and Excretion of [14C]Imidafenacin, a New Compound for Treatment of Overactive Bladder, After Oral Administration to Healthy Male Subjects
The absorption, metabolism, and excretion of imidafenacin [KRP-197/ONO-8025, 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide], a new antimuscarinic drug developed for treatment of overactiveExpand
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Circulatory, respiratory and metabolic changes after thigh tourniquet release in combined epidural‐propofol anaesthesia with preservation of spontaneous respiration
Twelve elderly patients undergoing total knee arthroplasty received lumbar epidural anaesthesia and propofol infusion at 5 mg.kg−1.h−1 following a 1.5–2.0 mg.kg−1 bolus dose with preservation ofExpand
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Propofol dosage achieving spontaneous breathing during balanced regional anesthesia with the laryngeal mask airway.
STUDY OBJECTIVE To assess an anesthetic technique achieving spontaneous breathing through the laryngeal mask airway (LMA) during combined epidural block and propofol anesthesia. DESIGN Prospective,Expand
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[The effect of acupuncture or electro-acupuncture on circulatory parameters].
We examined the effect of acupuncture or electro-acupuncture on circulatory parameters by use of a non-invasive procedure in 10 healthy male adult volunteers. Circulatory parameters measured wereExpand
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Inspired superoxide anions attenuate blood lactate concentrations in postoperative patients
ObjectiveLow concentrations of superoxide (O2−) constitute a portion of atmosphere negative ions in the form of O2−(H2O)n, which has been reported to have a stimulatory effect on superoxide dismutaseExpand
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