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Subregional Patterns of Preferential Striatal Dopamine Transporter Loss Differ in Parkinson Disease, Progressive Supranuclear Palsy, and Multiple-System Atrophy
TLDR
Compared with PD, PSP and MSA showed more prominent and earlier dopamine transporter loss in the AC and VP, respectively, which could be useful for suggesting PSP or MSA in parkinsonian cases without characteristic atypical features. Expand
Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment
TLDR
This work tested the hypothesis that lobar and deep CMBs are due to cerebral amyloid angiopathy and deep SVD, respectively, using structural magnetic resonance imaging (MRI) markers of subcortical SVD and in vivo imaging of amyloids in patients with cognitive impairment. Expand
Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate for Imaging xC− Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
TLDR
[18F]FSPG seems to be a promising tracer with a relatively high cancer detection rate in patients with NSCLC and PET may assess xC− transporter activity in Patients with cancer. Expand
High radiochemical yield synthesis of 3'-deoxy-3'-[18F]fluorothymidine using (5'-O-dimethoxytrityl-2'-deoxy-3'-O-nosyl-beta-D-threo pentofuranosyl)thymine and its 3-N-BOC-protected analogue as a
TLDR
After HPLC purification at neutral pH, the prepared 3'-deoxy-3'-[(18)F]fluorothymidine from 3'-O-nosyl thymidine derivative 3 or its pyrimidine ring N-BOC-protected analogue 5 achieved high radiochemical yields with radiochemical purities of >97%. Expand
[18F]3′-deoxy-3′-fluorothymidine PET for the diagnosis and grading of brain tumors
TLDR
Findings indicate that FLT PET is useful for evaluating tumor grade and cellular proliferation in brain tumors and displayed high sensitivity and good contrast in evaluating brain lesions that showed similar or decreased uptake compared with normal gray matter on FDG PET. Expand
[18F]Fluorothymidine Positron Emission Tomography before and 7 Days after Gefitinib Treatment Predicts Response in Patients with Advanced Adenocarcinoma of the Lung
TLDR
FLT- PET can predict response to gefitinib 7 days after treatment in nonsmokers with advanced adenocarcinoma of the lung, and the change in tumor SUVmax obtained by FLT-PET seems to be a promising predictive variable. Expand
Induction of thymidine kinase 1 after 5-fluorouracil as a mechanism for 3'-deoxy-3'-[18F]fluorothymidine flare.
TLDR
Investigation of the induction of thymidine kinase 1 (TK1) after 5-fluorouracil (5-FU) treatment as one of mechanisms for flare response in cell lines found 5-FU induced TK1 and Tk1-mediated high [(18)F]FLT flare in most of cell lines. Expand
Additional Value of Early-Phase 18F-FP-CIT PET Image for Differential Diagnosis of Atypical Parkinsonism
TLDR
18F-FP-CIT PETs with the first 10 minutes could be useful for the differential diagnosis of atypical Parkinson disorder by providing complementary FDG-like information to the dopamine transporter binding on late-phase FP-Cit images. Expand
In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles: mechanisms, key factors, and their implications.
TLDR
Evaluating various self-assembled nanoparticles as candidates to shuttle radionuclide and/or drugs into tumors and investigating the mechanisms underlying the tumor targeting with self- assembled nanoparticles to provide insight for the engineering of nanoparticles and be extended to cancer therapy and diagnosis. Expand
Fully automated synthesis system of 3'-deoxy-3'-[18F]fluorothymidine.
TLDR
A new fully automated method for the synthesis of 3'-deoxy-3'-[ 18F]fluorothymidine ([18F]FLT), by modifying a commercial FDG synthesizer and its disposable fluid pathway, combines high and reproducible yields with the benefits of a disposable cassette system. Expand
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