Channel-Mediated Tonic GABA Release from Glia
It is reported that tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation through the Bestrophin 1 (Best1) anion channel, and it is demonstrated that GABA directly permeates through Best1 to yield GABA release and that Tonic inhibition is eliminated by silencing of Best1.
The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4
The complete genome sequence of Zymomonas mobilis ZM4 (ATCC31821) is reported, an ethanologenic microorganism of interest for the production of fuel ethanol, which lacks recognizable genes for 6-phosphofructokinase, an essential enzyme in the Embden-Meyerhof-Parnas pathway, and for two enzymes in the tricarboxylic acid cycle.
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
It is proposed that selective inhibition of astrocytic GABA synthesis or release may serve as an effective therapeutic strategy for treating memory impairment in AD.
TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation
Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition
This work shows that glial gamma aminobutyric acid (GABA) is produced by monoamine oxidase B (MAOB), utilizing a polyamine, putrescine, to synthesize glial GABA, which is released to mediate tonic inhibition in the cerebellum and striatum.
Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development.
HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics
HepG2 cells are suggested as a cell-based model in screening for CYP inducers in drug discovery because of more similarity to human liver than the other cell lines in comparisons of the expression of cellular proteins.
Age-related changes in hepatic expression and activity of cytochrome P450 in male rats
The results suggest that age-related changes in hepatic CYP isoforms may be an important factor for deciding the efficacy and safety of xenobiotics.
Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells.
Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity
Ageing-associated changes in the innate and adaptive immunity and the impact of immunosenescence on viral infection and immunity are discussed and recent advances in strategies to enhance the immunogenicity of vaccines in the elderly are explored.