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Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain.
The results suggest that 3H-raclopride labels dopamine D-2 receptors with high specificity in the rat brain both in vitro and in vivo, and thus, that it should be a useful tool in studies of central dopamine D -2 receptors. Expand
Galanin, galanin receptor subtypes and depression-like behaviour.
The pathophysiology of depression remains unclear, but involves disturbances in brain monoaminergic transmission. Current antidepressant drugs, which act by enhancing this type of neurotransmission,Expand
Effects of repeated treatment of phencyclidine on cognition and gene expression in C57BL/6 mice.
It is demonstrated that repeated treatment with low doses of PCP in mice can produce specific cognitive deficits which are associated with alterations in gene expression in brain regions that appear to play a role in the pathophysiology of schizophrenia. Expand
Differential effects of the putative galanin receptor antagonists M15 and M35 on striatal acetylcholine release.
It is suggested that there may exist a putative subtype of galanin receptor in the striatum, which is differentially affected by M15 and M35, while M35 behaves as a mixed agonist-antagonist in vivo in the rat striatum. Expand
Neuropeptides in learning and memory processes with focus on galanin.
The results obtained with these neuropeptides in rodent studies indicate that they are important for various aspects of hippocampal learning and memory as well as hippocampal plasticity and compounds acting on Neuropeptide receptor subtypes will represent novel targets for a number of disorders, which involve cognitive deficiencies. Expand
5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT(1A) receptor stimulation on contextual learning in mice.
Findings indicate that 5-HT(7) receptor stimulation by 8-OH-DPAT counteracts 5- HT(1A) receptor-mediated impairments in hippocampal-dependent contextual learning. Expand
Effects of antidepressant drugs on different receptors in the brain.
  • H. Hall, S. Ogren
  • Chemistry, Medicine
  • European journal of pharmacology
  • 26 March 1981
Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors and found that all the antidepressants tested were practically devoid of activity on DHA binding, Spiroperidol binding, [3H]flunitrazepam binding, and Naloxone binding. Expand
Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides.
It was concluded that, besides the requirement of a lipophilic substituent in the position para to the methoxy group for antidopamine activity in vivo, the formation of a coplanar six-membered pseudoring involving the amide moiety and the meth oxygen group is a structural requirement for activity in vitro. Expand
Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides.
One compound, S-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxysalicylamide (raclopride, FLA 870) (13) had a stereotypy--hyperactivity separation more than twice that of sulpiride while being 100 times more potent in blocking the apomorphine effects. Expand