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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour… Expand
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.
- Aleksandar D. Kostic, D. Gevers, +15 authors M. Meyerson
- Biology, Medicine
- Genome research
- 1 February 2012
The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these… Expand
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
Background: The CpG island methylator phenotype (CIMP), characterised by widespread promoter methylation, is associated with microsatellite instability (MSI) and BRAF mutation in colorectal cancer.… Expand
Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel
- D. Rex, D. Ahnen, +16 authors J. Church
- The American Journal of Gastroenterology
- 1 September 2012
Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and account for a… Expand
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Aberrant activation of the canonical WNT/β-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated β-catenin activity… Expand
Molecular classification and correlates in colorectal cancer.
Molecular classification of colorectal cancer is evolving. As our understanding of colorectal carcinogenesis improves, we are incorporating new knowledge into the classification system. In… Expand
Restriction of intestinal stem cell expansion and the regenerative response by YAP
A remarkable feature of regenerative processes is their ability to halt proliferation once an organ’s structure has been restored. The Wnt signalling pathway is the major driving force for… Expand
Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of… Expand
Aspirin Use and Survival After Diagnosis of Colorectal Cancer
Randomized, placebo-controlled trials have shown that aspirin and other nonsteroidal anti-inflammatory agents significantly reduce the risk of adenomas and can prevent colorectal neoplasia. It is… Expand
RNF43 is frequently mutated in colorectal and endometrial cancers
We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating… Expand