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Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission
Transmission of HIV-1 via intercellular connections has been estimated as 100–1000 times more efficient than a cell-free process, perhaps in part explaining persistent viral spread in the presence ofExpand
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Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy
Super-resolution 3D imaging reveals remodeling of the cortical actin meshwork at the natural killer cell immune synapse, which is likely to be important for secretion of lytic granules.
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Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse
Vesicles dynamically deliver the T cell adaptor protein LAT to sites of T cell signalosomes. Submariner Adaptor Engagement of the T cell antigen receptor (TCR) on the surface of a T cell withExpand
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Matched Sizes of Activating and Inhibitory Receptor/Ligand Pairs Are Required for Optimal Signal Integration by Human Natural Killer Cells
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to testExpand
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High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells
Abstract Cholesterol- and glycosphingolipid-enriched membrane lipid microdomains, frequently called lipid rafts, are thought to play an important role in the spatial and temporal organization ofExpand
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Optical sectioning microscopes with no moving parts using a micro-stripe array light emitting diode.
We describe an optical sectioning microscopy system with no moving parts based on a micro-structured stripe-array light emitting diode (LED). By projecting arbitrary line or grid patterns onto theExpand
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High-speed high-resolution imaging of intercellular immune synapses using optical tweezers.
Imaging in any plane other than horizontal in a microscope typically requires a reconstruction from multiple optical slices that significantly decreases the spatial and temporal resolution that canExpand
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A role for septin 2 in Drp1‐mediated mitochondrial fission
Mitochondria are essential eukaryotic organelles often forming intricate networks. The overall network morphology is determined by mitochondrial fusion and fission. Among the multiple mechanisms thatExpand
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Conical diffraction as a versatile building block to implement new imaging modalities for superresolution in fluorescence microscopy
We present a new technology for super-resolution fluorescence imaging, based on conical diffraction. Conical diffraction is a linear, singular phenomenon taking place when a polarized beam isExpand
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