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Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission
Transmission of HIV-1 via intercellular connections has been estimated as 100–1000 times more efficient than a cell-free process, perhaps in part explaining persistent viral spread in the presence of… Expand
Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy
Super-resolution 3D imaging reveals remodeling of the cortical actin meshwork at the natural killer cell immune synapse, which is likely to be important for secretion of lytic granules.
Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse
Vesicles dynamically deliver the T cell adaptor protein LAT to sites of T cell signalosomes. Submariner Adaptor Engagement of the T cell antigen receptor (TCR) on the surface of a T cell with… Expand
Matched Sizes of Activating and Inhibitory Receptor/Ligand Pairs Are Required for Optimal Signal Integration by Human Natural Killer Cells
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test… Expand
High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells
Abstract Cholesterol- and glycosphingolipid-enriched membrane lipid microdomains, frequently called lipid rafts, are thought to play an important role in the spatial and temporal organization of… Expand
Optical sectioning microscopes with no moving parts using a micro-stripe array light emitting diode.
We describe an optical sectioning microscopy system with no moving parts based on a micro-structured stripe-array light emitting diode (LED). By projecting arbitrary line or grid patterns onto the… Expand
High-speed high-resolution imaging of intercellular immune synapses using optical tweezers.
Imaging in any plane other than horizontal in a microscope typically requires a reconstruction from multiple optical slices that significantly decreases the spatial and temporal resolution that can… Expand
A role for septin 2 in Drp1‐mediated mitochondrial fission
Mitochondria are essential eukaryotic organelles often forming intricate networks. The overall network morphology is determined by mitochondrial fusion and fission. Among the multiple mechanisms that… Expand
Conical diffraction as a versatile building block to implement new imaging modalities for superresolution in fluorescence microscopy
- Clément Fallet, J. Caron, +5 authors S. Shorte
- Physics, Engineering
- Optics & Photonics - NanoScience + Engineering
- 28 August 2014
We present a new technology for super-resolution fluorescence imaging, based on conical diffraction. Conical diffraction is a linear, singular phenomenon taking place when a polarized beam is… Expand