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Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.
Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of L-Trp and incorporates both atoms of a molecule of oxygen (O2). Here we report on the x-ray crystal structure ofExpand
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Crystallization and preliminary crystallographic studies of human indoleamine 2,3-dioxygenase.
Indoleamine 2,3-dioxygenase (IDO) is a haem-containing dioxygenase that catalyzes the oxidative cleavage of the pyrrole ring of indoleamines by the insertion of molecular oxygen. This reaction is theExpand
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  • Open Access
X-ray structure and reaction mechanism of human indoleamine 2,3-dioxygenase
Abstract The oxidative cleavage of the pyrrole ring of indoleamines by the insertion of molecular oxygen is catalyzed by indoleamine 2,3-dioxygenase (IDO). The reaction involves the addition of bothExpand
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