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Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.
TLDR
It is reported here that SIV-infected mangabeys maintain preserved T lymphocyte populations and regenerative capacity and manifest far lower levels of aberrant immune activation and apoptosis than are seen in pathogenic SIV and HIV infections.
Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys
TLDR
Based on the presence of the CypA insertion in separate macaque lineages, and its absence from sooty mangabeys, it is estimated that the Macaca TRIM5-CypA variant appeared 5–10 million years ago in a common ancestor of the Asian macaques.
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
TLDR
DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model, providing hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
TLDR
DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model, providing hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.
CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice.
TLDR
It is shown that lupus-prone NZB x NZW F(1) mice given three injections of anti-CD137 (4-1BB) mAb's between 26 and 35 weeks of age reversed acute disease, blocked chronic disease, and extended the mice's lifespan from 10 months to more than 2 years, supporting the hypothesis that CD137-mediated signaling anergized CD4(+) T cells during priming at the DC interface.
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
TLDR
DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model, providing hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.
Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1
TLDR
It is suggested that long-term passage of HIV-1 in chimpanzees can result in the development of a more pathogenic virus and be suggestive of a large quasispecies.
Identification of tubular injury microRNA biomarkers in urine: comparison of next-generation sequencing and qPCR-based profiling platforms
TLDR
This is the first time that miRNA profiling platforms including NGS have been compared in urine specimen and the results suggest that although miRNA-seq has superior specificity, it may not detect low abundant miRNAs in urine samples.
Critical Role for Env as well as Gag-Pol in Control of a Simian-Human Immunodeficiency Virus 89.6P Challenge by a DNA Prime/Recombinant Modified Vaccinia Virus Ankara Vaccine
TLDR
It is suggested that the rapid appearance of binding antibody for Env in Gag-Pol-Env-vaccinated animals helped protect uninfected CD4+ cells from Env-induced apoptosis and highlight the importance of immune responses to Env, as well as to GAG-Pol, in the control of immunodeficiency virus challenges and the protection of CD 4+ cells.
Probable Deceleration of Progression of Simian AIDS Affected by Opiate Dependency: Studies With a Rhesus Macaque/SIVsmm9 Model
TLDR
Long-term opiate dependency seemed to decelerate the rate of progression to AIDS in the SIVsmm9 monkey model, and this effect was most evident in monkeys with high initial viral titers/set points.
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