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Cannabinoids go nuclear: evidence for activation of peroxisome proliferator‐activated receptors
- S. O'Sullivan
- Biology, ChemistryBritish journal of pharmacology
- 1 November 2007
This review will summarize the published literature implicating cannabinoid‐mediated PPAR effects and discuss the implications thereof.
An update on PPAR activation by cannabinoids
- S. O'Sullivan
- BiologyBritish journal of pharmacology
- 1 June 2016
The aims of this review are to update the evidence supporting PPAR activation by cannabinoids and to review the physiological responses to cannabinoids that are mediated, and not mediated, by PPARactivation.
The complexities of the cardiovascular actions of cannabinoids
The cardiovascular actions of cannbinoids are complex and in conscious animals, the picture is one of bradycardia followed by pressor responses, but clearly the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies.
Time-dependent vascular actions of cannabidiol in the rat aorta.
A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
The paucity in data and some discrepancy in the pharmacokinetics of cannabidiol are highlighted, despite its widespread use in humans, and robust data from a variety of formulations is required.
Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma.
Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease.
Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα
- M. A. Karwad, Tara A. Macpherson, S. O'Sullivan
- BiologyFASEB journal : official publication of the…
- 1 February 2017
OEA and PEA have endogenous roles and potential therapeutic applications in conditions of intestinal hyperpermeability and inflammation and Preventing their degradation (by inhibiting fatty acid amide hydrolase) enhanced the effects of OEA andPEA.
Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries
There are differences in the mechanisms of vasorelaxation to anandamide between conduit and resistance mesenteric arteries, particularly in small resistance vessels and in the larger Mesenteric artery.
RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke
RIC after acute stroke is well tolerated and appears safe and feasible, and protective mechanisms may be mediated through HSP27.