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Molecular phylogenetics and the origins of placental mammals
TLDR
The potential weaknesses of limited character and taxon sampling are addressed in a comprehensive molecular phylogenetic analysis of 64 species sampled across all extant orders of placental mammals, providing new insight into the pattern of the early placental mammal radiation. Expand
A Molecular Phylogeny of Living Primates
TLDR
The resolution of the primate phylogeny provides an essential evolutionary framework with far-reaching applications including: human selection and adaptation, global emergence of zoonotic diseases, mammalian comparative genomics, primate taxonomy, and conservation of endangered species. Expand
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
TLDR
The CKR5Δ32 deletion may act as a recessive restriction gene against HIV-1 infection and may exert a dominant phenotype of delaying progression to AIDS among infected individuals. Expand
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
TLDR
The strongest synergistic effect of these loci was on progression to depletion of CD4+ T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection. Expand
The Late Miocene Radiation of Modern Felidae: A Genetic Assessment
TLDR
The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation. Expand
Placental mammal diversification and the Cretaceous–Tertiary boundary
TLDR
The largest available molecular data set for placental mammals is investigated, which includes segments of 19 nuclear and three mitochondrial genes for representatives of all extant placental orders and permits simultaneous constraints from the fossil record and allows rates of molecular evolution to vary on different branches of a phylogenetic tree. Expand
Whole-genome analyses resolve early branches in the tree of life of modern birds
TLDR
A genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves recovered a highly resolved tree that confirms previously controversial sister or close relationships and identifies the first divergence in Neoaves, two groups the authors named Passerea and Columbea. Expand
HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
TLDR
The extended survival of 28 to 40 percent of HIV-1-infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04, or to both. Expand
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
TLDR
The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV. Expand
A Molecular Phylogeny for Bats Illuminates Biogeography and the Fossil Record
TLDR
The results support the hypothesis that megabats are nested among four major microbat lineages, which originated in the early Eocene, coincident with a significant global rise in temperature, increase in plant diversity and abundance, and the zenith of Tertiary insect diversity. Expand
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