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Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
TLDR
It is concluded that intracerebral GDNF administration exerts both protective and reparative effects on the nigrostriatal dopamine system, which may have implications for the development of new treatment strategies for Parkinson's disease. Expand
Time‐dependent involvement of the dorsal hippocampus in trace fear conditioning in mice
TLDR
The results indicate that the dorsal hippocampus and its NMDA receptors play an important role in auditory trace fear conditioning at trace intervals of 15–30‐s length, and point at a time‐dependent role of the dorsal hippocampal in encoding of noncontingent explicit stimuli. Expand
Asphyctic lesion: proliferation of tyrosine hydroxylase-immunoreactive nerve cell bodies in the rat substantia nigra and functional changes in dopamine neurotransmission
TLDR
A significant decrease in rearing was observed in asphyctic animals during the habituation phase, as well as following apomorphine-induced (1 mg/kg s.c.) postsynaptic dopamine receptor stimulation. Expand
Acquisition, Expression, and Reinstatement of Ethanol-Induced Conditioned Place Preference in Mice: Effects of Opioid Receptor-Like 1 Receptor Agonists and Naloxone
TLDR
It is concluded that ORL1 agonists can modulate the acquisition, expression, and reinstatement of the conditioned reinforcing effects of ethanol with no reinforcing or aversive properties of their own. Expand
Reappearance of Hippocampal CA1 Neurons after Ischemia is Associated with Recovery of Learning and Memory
TLDR
The reappearance ofCA1 neurons was associated with a recovery of ischemia-induced impairments in spatial learning and memory at 90 DAI, suggesting that the newly formed CA1 neurons restore hippocampal CA1 function. Expand
Involvement of the 5-HT1A Receptors in Classical Fear Conditioning in C57BL/6J Mice
TLDR
It is concluded that the deficits in fear conditioning induced by 8-OH-DPAT are a result of postsynaptic 5-HT1Areceptor activation that interferes with learning processes operating at acquisition but not consolidation. Expand
Nogo receptor 1 regulates formation of lasting memories
TLDR
It is shown that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both passive avoidance and swim maze tests, and blocking transgene expression normalizes these memory impairments. Expand
Nociceptin/Orphanin FQ Microinjected into Hippocampus Impairs Spatial Learning in Rats
TLDR
The data suggest that nociceptin/orphanin FQ is a potent modulator of synaptic plasticity within the hippocampus. Expand
Differential Role of Galanin Receptors in the Regulation of Depression-Like Behavior and Monoamine/Stress-Related Genes at the Cell Body Level
TLDR
A differential role of galanin receptor subtypes in depression-like behavior in rodents is indicated: GalR1 subtype may mediate ‘prodepressive’ and GalR2 ‘antidepressant’ effects of Galanin. Expand
Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders
TLDR
The present paper chronicles the discovery and development of psychotropic agents, focusing in particular on their mechanisms of action and therapeutic utility, and how problems faced were eventually overcome. Expand
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