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Oncometabolites: tailoring our genes
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towardsExpand
A survival analysis of GBM patients in the West of Scotland pre- and post-introduction of the Stupp regime
Abstract Objective. It is now accepted that the concomitant administration of temozolomide with radiotherapy (Stupp regime), in the treatment of patients with newly diagnosed glioblastoma multiformeExpand
PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT
Highlights • The manuscript details the rationale, design and protocol for PARADIGM-2.• PARADIGM-2 comprises two parallel phase I, dose escalation studies of the PARP inhibitor olaparib inExpand
Phase I clinical trials evaluating olaparib in combination with radiotherapy (RT) and/or temozolomide (TMZ) in glioblastoma patients: Results of OPARATIC and PARADIGM phase I and early results of
2018Background: The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (O) has radio and chemosensitizing properties in GBM models. Clinical development of PARP inhibitor combinations has been r...
Current Advances in Checkpoint Inhibitors: Lessons from Non-Central Nervous System Cancers and Potential for Glioblastoma
The adaptive immune system depends on the sequence of antigen presentation, activation, and then inhibition to mount a proportionate response to a threat. Tumors evade the immune response partly byExpand
Partitioning Behaviour of Phenols Between Water and Hydrophilic/Hydrophobic Interfaces
In the actual discussion of sediment quality criteria the approaches of sediment-water equilibria being more oriented to basic science are of particular interest (Forstner 1989). Since sediments areExpand
Using alkaline peroxides for immobilizing phosphate in waters, soils, sediments and / or silts.
Using alkaline peroxides for immobilizing phosphate in waters of like stagnant and flowing waters and wastewaters, soils, sediments and / or silts.
PO-0667: Cardiac toxicity in lung cancer patients after chemo-radiotherapy (CART): a pilot study
Purpose/Objective: To determine if a weekly cone-beam CT (CBCT) is enough to evaluate the entire tumor inclusion and the reproducibility throughout the radiation course treatment in lung cancer.Expand