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Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line.
- C. Furuta, S. Noda, +4 authors K. Taya
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 15 May 2008
S steroidogenic enzymes are clarified as candidates responsible for the inhibition or stimulation for the production of steroid hormones in the steroidogenic pathway, thus providing the first experimental evidence for multiple mechanisms of disruption of endocrine pathways by these nitrophenols. Expand