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Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen Candida albicans
ABSTRACT Candida albicans is the most common human fungal pathogen and causes significant morbidity and mortality worldwide. Nevertheless, the basic principles of C. albicans pathogenesis remainExpand
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A Phenotypic Profile of the Candida albicans Regulatory Network
Candida albicans is a normal resident of the gastrointestinal tract and also the most prevalent fungal pathogen of humans. It last shared a common ancestor with the model yeast SaccharomycesExpand
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Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity
Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissectionExpand
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An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
The mammalian gastrointestinal tract and bloodstream are highly disparate biological niches that differ in concentrations of nutrients such as iron. However, some commensal-pathogenic microorganisms,Expand
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Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans
The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals. We utilized the completed genome sequence and optimized methods for homologous DNAExpand
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Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.
Here, we investigate how Candida albicans, the most prevalent human fungal pathogen, protects itself from nitric oxide (*NO), an antimicrobial compound produced by the innate immune system. We showExpand
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Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism
Among ∼5,000,000 fungal species, C. albicans is exceptional in its lifelong association with humans, either within the gastrointestinal microbiome or as an invasive pathogen. Opportunistic infectionsExpand
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Candida albicans cell-type switching and functional plasticity in the mammalian host
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal morphologies in C. albicansExpand
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An RNA Transport System in Candida albicans Regulates Hyphal Morphology and Invasive Growth
Localization of specific mRNAs is an important mechanism through which cells achieve polarity and direct asymmetric growth. Based on a framework established in Saccharomyces cerevisiae, we describe aExpand
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Candida albicans specializations for iron homeostasis: from commensalism to virulence.
  • S. Noble
  • Biology, Medicine
  • Current opinion in microbiology
  • 1 December 2013
Candida albicans is a fungal commensal-pathogen that persistently associates with its mammalian hosts. Between the commensal and pathogenic lifestyles, this microorganism inhabits host niches thatExpand
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