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RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
It is reported that inhibition of transmethylation reactions elongates the circadian period and methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)A-RNA methylation. Expand
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
A yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds is presented, and a new class of sterol-binding compounds is discovered. Expand
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
Ginkgolic acid and anacardic acid inhibit protein SUMOylation both in vitro and in vivo without affecting in vivo ubiquitination. Expand
Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.
- S. Nishimura, Y. Arita, +8 authors Minoru Yoshida
- Biology, Medicine
- Nature chemical biology
- 1 July 2010
Theonellamides, bicyclic peptides derived from marine sponges, represent a new class of sterol-binding molecules that induce membrane damage and activate Rho1-mediated 1,3-beta-D-glucan synthesis. Expand
Tetherin is an exosomal tether
- J. Edgar, Paul T Manna, S. Nishimura, G. Banting, M. Robinson
- Biology, Medicine
- 22 September 2016
Inactivating the vacuolar ATPase in HeLa cells causes a dramatic increase in the production of exosomes, which display endocytosed tracers, cholesterol, and CD63, and it is proposed that tetherin may play a key role in exosome fate, determining whether they participate in long-range or short-range interactions. Expand
13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit.
- S. Nishimura, S. Matsunaga, Minoru Yoshida, H. Hirota, S. Yokoyama, N. Fusetani
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 17 January 2005
Results indicate that 13-deoxytedanolide is a potent protein synthesis inhibitor and is the first macrolide to inhibit the eukaryotic ribosome. Expand
Inhibition of protein synthesis and activation of stress‐activated protein kinases by onnamide A and theopederin B, antitumor marine natural products
- Kun-Hyung Lee, S. Nishimura, S. Matsunaga, N. Fusetani, S. Horinouchi, Minoru Yoshida
- Biology, Medicine
- Cancer science
- 1 June 2005
The results suggest that onnamide A and theopedirin B trigger a ribotoxic stress‐like response, thereby inducing p38 kinase and JNK activation, the kinase‐dependent PAI‐1 gene expression, and apoptosis. Expand
Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
A novel microarray-based system using a set of drug-hypersensitive fission yeast strains that collectively overexpress each gene in the open reading frame-ome can accelerate the process of target identification of small molecules, which has the potential to reveal highly conserved genes of clinical relevance. Expand
Targeting cholesterol in a liquid-disordered environment by theonellamides modulates cell membrane order and cell shape.
It is shown that theonellamides, marine sponge-derived peptides, recognize cholesterol-containing liquid-disordered domains and induce phase separation in model lipid membranes, presenting a previously unrecognized mode of action of membrane-targeting natural products. Expand
Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.
Tumescenamide C, a new cyclic lipodepsipeptide, was isolated from a culture broth of an actinomycete Streptomyces sp. KUSC_F05. Tumescenamide C was a congener of tumescenamides A and B, representing… Expand