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A novel RNA motif that binds efficiently and specifically to the Tat protein of HIV and inhibits the trans‐activation by Tat of transcription in vitro and in vivo
To find a novel RNA that would bind efficiently and specifically to Tat protein but not to other cellular factors, we used an in vitro selection method and isolated a novel aptamer RNATat, a 37‐merExpand
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Detection and localization of a new enzyme catalyzing the β‐aryl ether cleavage in the soil bacterium (Pseudomonas paucimobilis SYK‐6)
Cleavage of the arylglycerol‐β‐aryl ether linkage is the most important process in the biological degradation of lignin. We determined the activity of the enzyme cleaving the β‐aryl ether linkage inExpand
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Isolation and characterization of RNA aptamers specific for the hepatitis C virus nonstructural protein 3 protease.
Nonstructural protein 3 (NS3) from hepatitis C virus (HCV) is a serine protease that provides an essential function in maturation of the virus by cleaving the nonstructural regions of the viralExpand
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Genetic and biochemical characterization of a 2-pyrone-4, 6-dicarboxylic acid hydrolase involved in the protocatechuate 4, 5-cleavage pathway of Sphingomonas paucimobilis SYK-6.
Sphingomonas paucimobilis SYK-6 is able to grow on a wide variety of dimeric lignin compounds with guaiacyl moieties, which are converted into protocatechuate by the actions of lignin degradationExpand
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Interferon-beta induction through toll-like receptor 3 depends on double-stranded RNA structure.
Type I interferons (IFN-alpha/beta) play an essential role in both innate and adaptive antiviral immune responses. IFN- beta is produced by fibroblasts and myeloid dendritic cells (DCs) upon viralExpand
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Characterization of Sphingomonas paucimobilis SYK-6 genes involved in degradation of lignin-related compounds
Sphingomonas paucimobilis SYK-6 is able to grow on a wide variety of dimeric lignin compounds. These compounds are degraded via vanillate and syringate by a unique enzymatic system, composed ofExpand
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Requirement of Runx1/AML1/PEBP2αB for the generation of haematopoietic cells from endothelial cells
Recent studies revealing that endothelial cells derived from E8.5‐E10.5 mouse embryos give rise to haematopoietic cells appear to correspond to previous histological observations that haematopoieticExpand
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Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.
Hepatitis C virus (HCV) is a single-stranded RNA virus and its genome is translated into a single large polyprotein. The viral-encoded NS3 protein possesses protease, nucleoside triphosphatase, andExpand
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RNA aptamers targeted to domain II of hepatitis C virus IRES that bind to its apical loop region.
The internal ribosome entry site (IRES) is important for translation of hepatitis C virus (HCV) mRNA and has a unique RNA structure containing conserved domains I to IV. To investigate the functionExpand
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Characterization and application of a novel RNA aptamer against the mouse prion protein.
In order to isolate RNA aptamers against the mouse prion protein (mPrP), we carried out in vitro selection from RNA pools containing a 30-nucleotide randomized region. Aptamer 60-3 was found to haveExpand
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