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Phylogenomics Reshuffles the Eukaryotic Supergroups
Background Resolving the phylogenetic relationships between eukaryotes is an ongoing challenge of evolutionary biology. In recent years, the accumulation of molecular data led to a new evolutionaryExpand
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The twilight of Heliozoa and rise of Rhizaria, an emerging supergroup of amoeboid eukaryotes.
Recent molecular phylogenetic studies revealed the extraordinary diversity of single-celled eukaryotes. However, the proper assessment of this diversity and accurate reconstruction of the eukaryoteExpand
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Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Basal cell carcinoma (BCC) of the skin is the most common malignant neoplasm in humans. BCC is primarily driven by the Sonic Hedgehog (Hh) pathway. However, its phenotypic variation remainsExpand
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Early History of Mammals Is Elucidated with the ENCODE Multiple Species Sequencing Data
Understanding the early evolution of placental mammals is one of the most challenging issues in mammalian phylogeny. Here, we addressed this question by using the sequence data of the ENCODEExpand
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Deep phylogeny and evolution of slime moulds (mycetozoa).
Mycetozoa, characterized by spore-bearing fruiting bodies, are the most diverse Amoebozoa. They traditionally comprise three taxa: Myxogastria, Dictyostelia and Protostelia. Myxogastria andExpand
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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells. All melanoma samples had high numbers of somaticExpand
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Phylogenetic position of Multicilia marina and the evolution of Amoebozoa.
Recent molecular phylogenetic studies have led to the erection of the phylum Amoebozoa, uniting naked and testate lobose amoebae, the mycetozoan slime moulds and amitochondriate amoeboid protistsExpand
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Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
BACKGROUND Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagicExpand
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The testate lobose amoebae (order Arcellinida Kent, 1880) finally find their home within Amoebozoa.
Testate lobose amoebae (order Arcellinida Kent, 1880) are common in all aquatic and terrestrial habitats, yet they are one of the last higher taxa of unicellular eukaryotes that has not found itsExpand
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Purifying selection in mammalian mitochondrial protein-coding genes is highly effective and congruent with evolution of nuclear genes.
The mammalian mitochondrial genomes differ from the nuclear genomes by maternal inheritance, absence of recombination, and higher mutation rate. All these differences decrease the effectiveExpand
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