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Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis
TLDR
It is reported that Six1 is required for the development of murine kidney, muscle and inner ear, and that it exhibits synergistic genetic interactions with Eya factors, and it is demonstrated that the Eya family has a protein phosphatase function, and its enzymatic activity is necessary for regulating genes encoding growth control and signalling molecules, modulating precursor cell proliferation.
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Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance*
TLDR
The findings suggest that inhibition of proteasome function induces heat-shock proteins and ER chaperones due to the accumulation of sufficient amounts of abnormal proteins and/or the inhibition of degradation of a key regulatory factor (e.g. heat- shock factor).
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Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease.
TLDR
It is concluded that urine metabolomics is a reliable source for biomarkers of diabetic complications, and the data suggest that renal organic ion transport and mitochondrial function are dysregulated in diabetic kidney disease.
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An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse.
TLDR
This cell line, mIMCD-3, retains many differentiated characteristics of this nephron segment including high transepithelial resistance, the presence of the amiloride-sensitive sodium channel as determined by Western blot analysis, and accumulation of the major organic osmolytes in response to hypertonic stress.
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Impaired Organic Anion Transport in Kidney and Choroid Plexus of Organic Anion Transporter 3 (Oat3 (Slc22a8)) Knockout Mice*
TLDR
A targeted disruption of the murine organic anion transporter 3 (Oat3) gene is carried out to indicate a key role for Oat3 in systemic detoxification and in control of the organic anions distribution in cerebrospinal fluid.
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What do drug transporters really do?
  • S. Nigam
  • Biology, Medicine
    Nature Reviews Drug Discovery
  • 2015
TLDR
Evidence is discussed for the roles of ABC and SLC transporters in the handling of diverse substrates, including metabolites, antioxidants, signalling molecules, hormones, nutrients and neurotransmitters, which may help to clarify disease mechanisms, drug–metabolite interactions and drug effects relevant to diabetes, chronic kidney disease, metabolic syndrome, hypertension, gout, liver disease, neuropsychiatric disorders, inflammatory syndromes and organ injury.
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Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney*
TLDR
Analysis of the deduced 546-amino acid protein sequence indicates that NKT is a unique gene product which shares a similar transmembrane domain hydropathy profile as well as transporter-specific amino acid motifs with a variety of bacterial and mammalian nutrient transporters.
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Acute renal failure. II. Experimental models of acute renal failure: imperfect but indispensable.
TLDR
This review aims to evaluate the relevance and utility of the experimental models currently available to study ischemic and toxic renal injury, to suggest novel experimental approaches and models that have the potential to provide advantages over methods currently available and to discuss the difficulties inherent in clinical studies of ATN.
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Regulated assembly of tight junctions by protein kinase C.
TLDR
The data indicate that protein kinase C (PKC) is required for the proper assembly of tight junctions, and in vitro measurements indicate that ZO-1 may be a direct target of PKC.
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Organic anion and cation transporters occur in pairs of similar and similarly expressed genes.
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