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Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness.
TLDR
A mysterious respiratory illness with high mortality was recently reported in the southwestern United States and nucleotide sequence analysis revealed the associated virus to be a new hantavirus and provided a direct genetic link between infection in patients and rodents. Expand
Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda
TLDR
Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines. Expand
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
TLDR
Chloroquine is effective in preventing the spread of SARS CoV in cell culture and the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds. Expand
The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing.
TLDR
Phylogenetic analysis indicates that EBO virus subtypes are genetically diverse and that the recent Ivory Coast isolate represents a new (fourth) subtype of EBO Virus, and is virtually identical to the virus that caused a similar epidemic in Yambuku, Zaire almost 20 years earlier. Expand
Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation.
TLDR
It is demonstrated that the EBOV VP24 protein functions as an inhibitor ofIFN-alpha/beta and IFN-gamma signaling, and suggests that VP24 is likely to be an important virulence determinant that allows E BOV to evade the antiviral effects of IFNs. Expand
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
TLDR
The etymological derivation of individual names, their pronunciation, and their correct use are explained, and demarcation criteria for each taxon and virus are elaborate. Expand
Discovery of Swine as a Host for the Reston ebolavirus
TLDR
Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV), the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. Expand
Estimating the future number of cases in the Ebola epidemic--Liberia and Sierra Leone, 2014-2015.
TLDR
A modeling tool was constructed to provide estimates of the potential number of future cases of the current West African epidemic of Ebola and how control and prevention interventions can slow and eventually stop the epidemic. Expand
Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats
TLDR
Data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans. Expand
Rapid evolution of RNA genomes.
TLDR
RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication, and high rates of replication reflected in rates of RNA genome evolution which can be more than a millionfold greater than the rates of the DNA chromosome evolution of their hosts. Expand
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