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SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells.
- Gary K Yiu, W. Y. Chan, +4 authors S. Mok
- Biology, Medicine
- The American journal of pathology
- 1 August 2001
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular Ca(2+)-binding matricellular glycoprotein that associates with cell populations undergoing migration, morphogenesis, and… Expand
Expression of Nitric Oxide Synthase Isoforms and Nitric Oxide Production in Acute Pancreatitis and Associated Lung Injury
Background/Aims: The role of nitric oxide (NO) has been increasingly implicated in the pathophysiology of acute pancreatitis (AP). Studies have shown increased NO production in AP although not all… Expand
Role of MCP-1 in endotoxemia and sepsis.
Sepsis is a complex clinical syndrome resulting from a harmful host inflammatory response to infection. Similarly, lipopolysaccharide (LPS) induced endotoxemia is marked by the activation of… Expand
Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+ Influx through Ca2+ Release-activated Ca2+ Channels*
- S. Ng, Joseph di Capite, Karthika Singaravelu, A. Parekh
- Biology, Medicine
- Journal of Biological Chemistry
- 14 November 2008
Mast cell activation involves cross-linking of IgE receptors followed by phosphorylation of the non-receptor tyrosine kinase Syk. This results in activation of the plasma membrane-bound enzyme… Expand
Decoding of Cytoplasmic Ca2+ Oscillations through the Spatial Signature Drives Gene Expression
Cytoplasmic Ca(2+) oscillations are a universal signaling mode that activates numerous cellular responses [1, 2]. Oscillations are considered the physiological mechanism of Ca(2+) signaling because… Expand
Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis
BackgroundHydrogen sulfide (H2S), a gaseous mediator plays an important role in a wide range of physiological and pathological processes. H2S has been extensively studied for its various roles in… Expand
Hydrogen Sulfide Up-Regulates Substance P in Polymicrobial Sepsis-Associated Lung Injury1
- H. Zhang, A. Hegde, S. Ng, Sharmila Adhikari, S. Moochhala, M. Bhatia
- The Journal of Immunology
- 15 September 2007
Hydrogen sulfide (H2S) has been shown to induce the activation of neurogenic inflammation especially in normal airways and urinary bladder. However, whether endogenous H2S would regulate… Expand
T1301 Serum Hydrogen Sulfide and Substance P Are Early Clinical Predictors of the Severity of Acute Pancreatitis
Background and aims: The incidence and clinical course of the pancreatic pseudocyst is expected to be changed due to the recent advance in various diagnosis and treatment modalities. The aims of this… Expand
Effect of tumour necrosis factor on growth of Ehrlich ascites tumour cells in vitro and in vivo.
Tumour necrosis factor (TNF) suppressed the growth of Ehrlich ascites tumour (EAT) cells in vitro and in vivo. Exposure of EAT cells to TNF for as little as 4 h totally abolished the… Expand
Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.
- V. Chan, S. Ng, J. Eder, L. Schnipper
- Medicine, Biology
- The Journal of biological chemistry
- 25 January 1993
Topoisomerase II (Top II) is the target enzyme for many antineoplastic drugs such as epipodophyllotoxins, anthracyclines, and acridines. Cell lines with alterations in Top II are resistant to drugs… Expand