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Activity-dependent scaling of quantal amplitude in neocortical neurons
Information is stored in neural circuits through long-lasting changes in synaptic strengths,. Most studies of information storage have focused on mechanisms such as long-term potentiation andExpand
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Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity
Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among inputs, but how these factors interact during realistic patterns of activity is unknown. Here we monitoredExpand
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Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits
How different is local cortical circuitry from a random network? To answer this question, we probed synaptic connections with several hundred simultaneous quadruple whole-cell recordings from layer 5Expand
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A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex
A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling the diversity of GABAergic interneurons. This diversity poses general questions for neural circuitExpand
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Synaptic plasticity: taming the beast
Synaptic plasticity provides the basis for most models of learning, memory and development in neural circuits. To generate realistic results, synapse-specific Hebbian forms of plasticity, such asExpand
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Synaptic Depression and Cortical Gain Control
Cortical neurons receive synaptic inputs from thousands of afferents that fire action potentials at rates ranging from less than 1 hertz to more than 200 hertz. Both the number of afferents and theirExpand
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Homeostatic plasticity in the developing nervous system
Activity has an important role in refining synaptic connectivity during development, in part through 'Hebbian' mechanisms such as long-term potentiation and long-term depression. However, HebbianExpand
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Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid Receptors
There is a consensus that NMDA receptors (NMDARs) detect coincident pre- and postsynaptic activity during induction of long-term potentiation (LTP), but their role in timing-dependent long-termExpand
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An emergent model of orientation selectivity in cat visual cortical simple cells
It is well known that visual cortical neurons respond vigorously to a limited range of stimulus orientations, while their primary afferent inputs, neurons in the lateral geniculate nucleus (LGN),Expand
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A Quantitative Description of Short-Term Plasticity at Excitatory Synapses in Layer 2/3 of Rat Primary Visual Cortex
Cortical synapses exhibit several forms of short-term plasticity, but the contribution of this plasticity to visual response dynamics is unknown. In part, this is because the simple patterns ofExpand
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