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The cytotoxicity of eosinophil cationic protein/ribonuclease 3 on eukaryotic cell lines takes place through its aggregation on the cell membrane
Abstract.Human eosinophil cationic protein (ECP)/ ribonuclease 3 (RNase 3) is a protein secreted from the secondary granules of activated eosinophils. Specific properties of ECP contribute to itsExpand
Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines
The effects of supernatant from the bacterial strain Serratia marcescens 2170 (CS‐2170) on the viability of different haematopoietic cancer cell lines (Jurkat, NSO, HL‐60 and Ramos) and nonmalignantExpand
Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals
Biofilms are communities of bacteria that grow encased in an extracellular matrix that often contains proteins. The spatial organization and the molecular interactions between matrix scaffoldExpand
Eosinophil cationic protein high-affinity binding to bacteria-wall lipopolysaccharides and peptidoglycans.
The eosinophil cationic protein (ECP) is an eosinophil-secreted RNase involved in the immune host defense, with a cytotoxic activity against a wide range of pathogens. The protein displaysExpand
Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferation
Eosinophil cationic protein (ECP) is a ribonuclease secreted from activated eosinophils that may cause tissue injure as a result of eosinophilic inflammation. ECP possesses bactericidal, antiviralExpand
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Significance Parkinson’s disease is characterized by the accumulation of amyloid deposits in dopaminergic neurons, mainly composed of the protein α-synuclein. The disordered nature of α-synuclein andExpand
A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation
BackgroundRibonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxicExpand
The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation
Abstractα-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular,Expand
Dissecting the contribution of Staphylococcus aureus α-phenol-soluble modulins to biofilm amyloid structure
The opportunistic pathogen Staphylococcus aureus is recognized as one of the most frequent causes of biofilm-associated infections. The recently discovered phenol soluble modulins (PSMs) are smallExpand
Protein aggregation into insoluble deposits protects from oxidative stress
Protein misfolding and aggregation have been associated with the onset of neurodegenerative disorders. Recent studies demonstrate that the aggregation process can result in a high diversity ofExpand