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Bioavailability of two single-dose oral formulations of omeprazole 20 mg: an open-label, randomized sequence, two-period crossover comparison in healthy Mexican adult volunteers.
TLDR
In this small study in healthy Mexican adult volunteers, a single, 20-mg dose of the test formulation appeared to be bioequivalent to the reference formulation, based on the rate and extent of absorption, and both formulations were generally well tolerated. Expand
Development and Validation of a High-Performance Thin-Layer Chromatographic Method, with Densitometry, for Quantitative Analysis of Tizoxanide (a Metabolite of Nitazoxanide) in Human Plasma
A new simple, rapid, and selective high-performance thin-layer chromatographic (HPTLC) method with metronidazole as the internal standard has been developed for analysis of tizoxanide (a metaboliteExpand
Bioavailability of two oral suspension and two oral tablet formulations of acyclovir 400 mg: two single-dose, open-label, randomized, two-period crossover comparisons in healthy Mexican adult
TLDR
The aim of these 2 studies was to compare the bioavailability of 4 oral formulations of acyclovir 400 mg--2 tablet formulations and 2 suspension formulations--with their corresponding listed drug references in Mexico (a list issued by Mexican Health Authorities). Expand
Development and Validation of a Densitometric HPTLC Method for Quantitative Analysis of Levofloxacin in Human Plasma
Levofloxacin, (–)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, is an advanced-generation fluoroquinolone antibiotic. ItExpand
Bioavailability of two oral formulations of azithromycin 500 mg: a randomized, open-label, two-period crossover comparison in healthy Mexican adult subjects.
TLDR
In this small study in healthy Mexican volunteers, a single, 500-mg dose of Macrozit was found to be bioequivalent to that of Azitrocin based on the rate and extent of absorption, and both formulations were well tolerated. Expand
Development and validation of a high-performance thin-layer chromatographic method, with densitometry, for quantitative analysis of ketorolac tromethamine in human plasma.
TLDR
The method proved to be accurate, precise, and sensitive for the ketorolac tromethamine quantification and was validated for precision, accuracy, and sensitivity. Expand
Bioavailability of two oral formulations of a single dose of levofloxacin 500 mg: an open-label, randomized, two-period crossover comparison in healthy Mexican volunteers.
TLDR
In this small study in healthy, fasting Mexican adults, a single 500-mg dose of the test formulation of orally administered levofloxacin met the regulatory requirements to assume bioequivalence based on the rate and extent of absorption. Expand
Bioavailability of two sublingual formulations of ketorolac tromethamine 30 mg: a randomized, open-label, single-dose, two-period crossover comparison in healthy Mexican adult volunteers.
TLDR
In this small study in 27 healthy Mexican adult volunteers, the test formulation of a single, 30-mg sublingual tablet of ketorolac appeared to be bioequivalent to the reference formulation based on the rate and extent of absorption, and both formulations were well tolerated. Expand
Quantification of 4-aminopyridine in plasma by capillary electrophoresis with electrokinetic injection.
TLDR
This method was successfully applied to the quantification of 4-aminopyridine (4-AP) in plasma samples from patients with spinal cord injury. Expand
Bioavailability of two oral-tablet and two oral-suspension formulations of naproxen sodium/paracetamol (acetaminophen): single-dose, randomized, open-label, two-period crossover comparisons in
TLDR
Tolerability was determined by clinical assessment, monitoring vital signs, laboratory analysis results, and subject interviews regarding adverse events, and the formulations were considered bioequivalent if the geometric mean ratios (test/reference) of the C(max) and AUC were within the predetermined range of 80% to 125%. Expand
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