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Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity
Neural induction by SDIA provides a new powerful tool for both basic neuroscience research and therapeutic applications. Expand
Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction.
Zic-r1 acts in the pathway bridging the neural inducer with the downstream proneural genes, while Sox-2 makes the ectoderm responsive to extracellular signals, demonstrating that the early phase of neural induction involves simultaneous activation of multiple functions. Expand
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
It is demonstrated that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation in neural precursor cells prepared from wild‐type, Hes1‐null, Hes5‐null and Hes1-Hes5 double‐null mouse embryos. Expand
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.
The results suggest that HES-1 may play an important role in mammalian development by negatively acting on the two different sequences while Hes-3 acts as a repressor in a specific type of neurons. Expand
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
Results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis. Expand
A Mammalian Helix-Loop-Helix Factor Structurally Related to the Product of Drosophila Proneural Gene atonal Is a Positive Transcriptional Regulator Expressed in the Developing Nervous System(*)
The results suggest that MATH-1 may be a target of HES-1 and play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Expand
Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system.
We report here the cDNA cloning and characterization of a rat basic helix-loop-helix (HLH) factor, designated HES-5. This factor has a distant sequence homology to Drosophila hairy andExpand
Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm.
It is shown that Sox2 function is required for neural differentiation of early Xenopus ectoderm and Sox2-class genes are essential for early neuroectoderm cells to consolidate their neural identity during secondary steps of neural differentiation. Expand
Conversion of ectoderm into a neural fate by ATH‐3, a vertebrate basic helix–loop–helix gene homologous to Drosophila proneural gene atonal
Evidence is provided that ATH‐3 can directly convert non‐neural or undetermined cells into a neural fate, and it is suggested that the Ser residue in the basic region may be critical for the regulation of A TH‐3 activity by phosphorylation. Expand
Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system.
The transition from the initial growth phase of dividing precursor cells and the subsequent differentiation phase of postmitotic cells is controlled antagonistically by multiple helix-loop-helix (HLH) genes. Expand