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Purification and characterization of sarcosine oxidase of Bacillus origin.
Sarcosine oxidase (EC produced by Bacillus sp. B-0618 was purified by ion exchange chromatography on diethyl aminoethyl-cellulose and gel filtration on Sephadex G-100 and G-150. TheExpand
In vitro antiviral activity of polyoxomolybdates. Mechanism of inhibitory effect of PM-104 (NH4)12H2(Eu4(MoO4)(H2O)16(Mo7O24)4).13H2O on human immunodeficiency virus type 1.
PM-104 interferes with virus infection at a very early step such as adsorption and/or penetration into the cells, and blocks the replication of herpes simplex virus type 1 (HSV-1) and type 2 ( HSV-2). Expand
New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis.
The carbazomycin-producing microorganism, strain H 1051-MY 10, was determined to a strain of Streptoverticillium ehimense and neither of the labeled carbons, [1-14C]tryptophan nor [2,3-13C]propionic acid, was detected in the antibiotic, and a progenitor of the C-2 and C-11 moiety of the antibiotic has not been determined. Expand
Role of the naphthoquinone moiety in the biological activities of sakyomicin A.
Juglone (5-hydroxy-1,4-naphthoquinone) which resembles the partial structure of sakyomicin A was the most active in cytotoxicity against murine lymphosarcoma L5178Y cells, electron acceptor function in the oxidation of NADH by Clostridium kluyveri diaphorase or rat liver mitochondria and inhibition against avian myeloblastosis virus reverse transcriptase. Expand
The structures of component A1 (= LL-AB664) and component A2 (= LL-AC541), streptothricin-like antibiotics.
Two streptothricin-like antibiotics effective against Serratia marcescens, tentatively designated as components A1 and A2, were isolated from broth filtrate of Streptoverticillium olivoreticuli to determine the location of the carbamoyl group on the aminosugar. Expand
Characterization and active fragment of phenomycin, an antitumor polypeptide antibiotic.
New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties.
An unidentified Streptomyces, designated as Strain H 1051-MY 10, was proved to produce viomycin and two new antibiotics, which inhibited the growth of phytophathogenic fungi and further showed weak antibacterial and antiyeast activities. Expand
Comparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases.
The inhibition of human immunodeficiency virus (HIV) reverse transcriptase by certain antibiotics and related compounds was studied in comparison with that of avian myeloblastosis virus (AMV) reverseExpand
Biological properties of streptonigrin derivatives. II. Inhibition of reverse transcriptase activity.
Antitumor antibiotic streptonigrin (STN-COOH) is a potent inhibitor of avian myeloblastosis virus (AMV) and human immunodeficiency virus reverse transcriptases and doxorubicin-resistant murine lymphoblastoma L5178Y cells showed collateral sensitivity to both STN- COOH and STN (CH2)3N(CH3)2 not only in vitro but also in vivo. Expand
Biological properties of streptonigrin derivatives. I. Antimicrobial and cytocidal activities.