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Biological activities of chemically synthesized 2-keto-3-deoxyoctonic acid-(alpha 2----6)-D-glucosamine analogs of lipid A
TLDR
Findings indicate that the addition of 2-keto-3-deoxyoctonic acid enhances the mitogenic activity of 2,3-diacyloxyacylglucosamine-4-phosphate but does not affect the lethal toxicity and the induction of Shwartzman reaction in rabbits.
Antitumor activity and biological effects of chemically synthesized monosaccharide analogues of lipid A in mice.
TLDR
Five synthetic monosaccharide analogues of lipid A containing two 3-acyloxytetradecanoyl and a phosphoryl group at the C-2, -3 and -4 positions of the glucosamine skelton were synthesized and the antitumor activity of these compounds against the ascites form of Ehrlich carcinoma was compared with those of a bacterial lipopolysaccharide or lipid A.
Antitumor activity and lethal toxicity of chemically synthesized tetraacetyl-2-keto-3-deoxyoctonic acid-(alpha 2---6)-D-glucosamine analogues of lipid A.
TLDR
Although the antitumor activity of the compounds against ascites form of Ehrlich carcinoma in ddY mice was weaker than that of natural lipopolysaccharide, compound A-203, with di-3-tetradecanoyloxytetrade canoyl at the C-2 and C-3 positions, was effective and lethal toxicity of A-205 was most potent among the three compounds.
Antitumor activity, mitogenicity, and lethal toxicity of chemically synthesized monosaccharide analogs of lipid A.
TLDR
Antitumor activity of three derivatives of chemically synthesized diacyloxyacylglucosamine-4-phosphate and the acyl-GlcN-4P linked KDO was weaker than that of the natural lipopolysaccharide, however, KDO-attachment appeared not to enhance the antitumorActivity.
Combined effects of synthetic lipid A analogs and muramyl dipeptide on antitumor activity against Meth A fibrosarcoma in mice.
TLDR
L929 cell lysis by the combination of A-171, A-172 with MDP was higher than that by the analogs or MDP alone, suggesting that the lipid A analogs of monosaccharide type as well as LPS are able to enhance the production of tumor necrosis factor in the presence of MDP.
Efficient synthesis of novel monosaccharide analogs of lipids A.
The efficient synthesis of the monosaccharide analogs of lipids A bearing two 3-acyloxytetradecanoyl and phosphoryl groups at the C-2, 3 and C-4 positions of the glucosamine skeleton is described.
Antitumor activity against Meth A fibrosarcoma and biologic activities of synthetic monosaccharide analogs of lipid A in mice.
TLDR
The results discussed above indicate that the biologic activity of these compounds correlates with the carbon number of fatty acid but is not affected by the different location of the phosphate group, and it seems that the difference between the alpha, beta-hydroxy position of fatty acids and the R or S configuration does not alter theBiologic effects.
Lipid A and related compounds. XVII. Synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO)-(alpha 2----6)-D-glucosamine-4-phosphates, analogs of the biologically active moiety of lipopolysaccharide
Synthesis of biologically active 3-deoxy-D-manno-2-octulosonic acid (KDO)-(α2→6)-D-glucosamine-4-phosphate analogs of lipid A is described.
Mitogenic activity of chemically synthesized tetraacetyl-2-keto-3-deoxyoctonic acid-(alpha 2----6)-D-glucosamine analogues of lipid A.
TLDR
Three derivatives of 4-O-monophosphorylglucosamine-linked tetraacetyl-2-keto-3-deoxyoctonic acid were capable of increasing the incorporation of 3H-thymidine into splenocytes of C57BL/6 mice in vitro.
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