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Vasodilatation Induced by Pinacidil in Dogs. Comparison with Hydralazine and Nifedipine
- N. Toda, S. Nakajima, M. Miyazaki, M. Ueda
- Journal of cardiovascular pharmacology
- 1 November 1985
It may be concluded that pinacidil produces vasodilatation due to interference with the transmembrane influx of Ca2+ into smooth muscle evoked by receptor stimulation but not that due to inhibition in the Ca2- influx associated with K+-induced membrane depolarization. Expand
Spatial changes of [Ca2+]i and contraction caused by phorbol esters in vascular smooth muscle cells.
The results suggest that PKC activation induces cellular contractions through two distinct mechanisms, one dependent on and another independent of the [Ca2+]i increase. Expand
A novel non‐peptide endothelin antagonist isolated from bayberry, Myrica cerifera
- M. Fujimoto, S. Mihara, S. Nakajima, M. Ueda, M. Nakamura, K. Sakurai
- Medicine, Biology
- FEBS letters
- 22 June 1992
A potent non‐peptide ET receptor antagonist, myrireron caffeoyl ester (50–235), was isolated from the bayberry and can be useful for studying the physiological role of endothelin and exploring its role in various diseases. Expand
Kinetic studies on the interaction of nonlabeled antagonists with the angiotensin II receptor.
- M. Hara, R. Kiyama, +6 authors M. Fujimoto
- Chemistry, Medicine
- European journal of pharmacology
- 28 April 1995
The kinetic properties of SRL1080227, CV11974 and FK739 were consistent with their characteristic modes in inhibiting angiotensin II-induced contraction of isolated rabbit aorta and decreasing blood pressure of spontaneously hypertensive rats. Expand
Neuropeptide YY1 receptors-mediated increase in intracellular Ca2+ concentration via phospholipase C-dependent pathway in porcine aortic smooth muscle cells.
It is suggested that NPY-induced Ca2+ mobilization from intracellular stores in porcine smooth muscle cells is secondary to the very small generation of Ins(1,4,5)P3 following stimulation of phospholipase C-beta, which may account for the hypersensitivity of the NPY effect to U73122. Expand
A dicarba analog of β‐atrial natriuretic peptide (β‐ANP) inhibits guanosine 3′,5′‐cyclic monophosphate production induced by α‐ANP in cultured rat vascular smooth muscle cells
The synthesis and biological properties are described of [Asu7,23′]‐β‐ANP‐(7–28) (Asu, L‐α‐aminosuberic acid), a dicarba analog of β‐atrial natriuretic peptide (β‐ANP, an antiparallel dimer of human… Expand
Application of Monoclonal Antibodies for Endothelin to Hypertensive Research
The present study demonstrates the elevated plasma ET-l-LI level in patients with essential hypertension and monoclonal antibodies developed in this study can become powerful tools to investigate the pathophysiological significance of ET in essential hypertension. Expand
Pharmacological characterization of a potent nonpeptide endothelin receptor antagonist, 97-139.
- S. Mihara, S. Nakajima, S. Matumura, T. Kohnoike, M. Fujimoto
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 1994
The endothelin (ET) receptor antagonist activity of 97-139 was studied and the in vivo potency was almost the same as that of BQ-123, although the potencies in binding assays and in vitro functional assays were about one order of magnitude higher than those of B Q-123. Expand
A study on the hypotensive mechanism of pinacidil: relationship between its vasodilating effect and intracellular Ca2+ levels.
- S. Nakajima, K. Kurokawa, N. Imamura, M. Ueda
- Biology, Medicine
- Japanese journal of pharmacology
- 1 February 1989
Results indicate thatPinacidil, like nifedipine and hydralazine, do not seem to directly act on the process from the formation of Ca2+-calmodulin to the actinmyosin interaction in the contracting mechanism of vascular smooth muscle, and that pinacidil relaxes the vascular smooth Muscle by decreasing intracellular Ca2-levels without elevating cyclic nucleotides. Expand
Effects of S-312, a new calcium antagonist, on the mechanical and electrophysiological responses of isolated cardiovascular preparations.
The present results indicate that S-312 is a potent new calcium antagonist possessing vasculoselectivity, especially for cerebral vessels. Expand