• Publications
  • Influence
The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition.
With increasing use of plant-derived cancer chemotherapeutic agents, exploring the antiproliferative effects of phytochemicals has gained increasing momentum for anticancer drug design. The dietaryExpand
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Assessment of risk factors for oral squamous cell carcinoma in Chidambaram, Southern India: a case–control study
Oral squamous cell carcinoma, the fifth most common cancer worldwide, is a major cause of morbidity and mortality in India. The effect of lifestyle factors, including tobacco chewing, smoking andExpand
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The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells
Abstract Limonoids from the neem tree (Azadirachta indica) have attracted considerable research attention in recent years owing to their potent antioxidant and anti-proliferative effects. The presentExpand
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Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast.
OBJECTIVES To correlate the extent of lipid peroxidation with the antioxidant status in the circulation of patients with fibroadenoma and adenocarcinoma of the breast. DESIGN AND METHODS TenExpand
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Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention.
  • S. Nagini
  • Medicine
  • World journal of gastrointestinal oncology
  • 15 July 2012
Carcinoma of the stomach is still the second most common cause of cancer death worldwide, although the incidence and mortality have fallen dramatically over the last 50 years in many regions. TheExpand
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Cytochrome P450 Structure, Function and Clinical Significance: A Review.
BACKGROUND The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction orExpand
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Medicinal properties of neem leaves: a review.
Azadirachta indica, commonly known as neem, has attracted worldwide prominence in recent years, owing to its wide range of medicinal properties. Neem has been extensively used in Ayurveda, Unani andExpand
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Breast Cancer: Current Molecular Therapeutic Targets and New Players.
  • S. Nagini
  • Medicine, Biology
  • Anti-cancer agents in medicinal chemistry
  • 31 January 2017
Breast cancer is the most common cancer and the most frequent cause of cancer death among women worldwide. Breast cancer is a complex, heterogeneous disease classified into hormone-receptor-positive,Expand
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The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis
SummaryLimonoids from the neem tree (Azadirachta indica) have attracted considerable research attention for their cytotoxicity against human cancer cell lines. However, the antiproliferative andExpand
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Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer.
BACKGROUND The oncogenic transcription factors NF-κB and β-catenin, constitutively activated by upstream serine/threonine kinases control several cellular processes implicated in malignantExpand
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