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Supramolecular assemblies of DNA with neutral nucleoside amphiphiles.
AFM studies show that the three distinct structural components of the amphiphile are required for the formation of DNA-amphiphile supramolecular assemblies on a mica surface.
Synthesis and characterization of pi-stacked phenothiazine-labeled oligodeoxynucleotides.
A facile procedure for the incorporation of N-methyl phenothiazine as the terminal nucleoside in oligodeoxynucleotides is reported, which forms stable B-form duplexes with higher melting temperatures compared to unlabeled DNA duplexe.
Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents.
The synthesis of Cordycepin and 2'-O-methyl alpha-P-borano triphosphate via a one-pot phosphorochloridite synthesis under mild conditions is shown and these analogues will be used for future structure-activity relationship (SAR) studies.
6-N-1 Trobenzotriazol-1-Yloxytris(Dimethylamino)Phosphonium Hexafluorophosphate (NBOP): A New Coupling Reagent in Oligonucleotide Synthesis
Abstract 6-Nitrobenzotriazol-1-yloxytris(dimethylamino) phosphonium hexafluorophosphate (NBOP, 2) has been demonstrated as an efficient coupling reagent in oligonucleotide synthesis. The reagent is
Synthesis and Separation of Dinucleoside Phenylphosphonate Diastereomers
Abstract Dinucleoside phenylphosphonates have been synthesized in excellent yields using 6-Nitrobenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (NBOP) as a coupling reagent. A
Synthesis of 9-Fluorenemethyl Boranophosphonodiphosphate Via an H-Phosphonate Approach
The H-phosphonate approach is efficient for the synthesis of acyclic compounds 6 & 7, and can be explored forThe synthesis of nucleoside 5′-deoxy boranophosphonodiphosphate.