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Detoxification of vinyl carbamate epoxide by glutathione: evidence for participation of glutathione S-transferases in metabolism of ethyl carbamate.
TLDR
VCO can be detoxified by spontaneous conjugation with GSH, conjugations of VCO with GST can be catalyzed by GST(s), pretreatment with BHA protects against binding of active EC metabolites in vitro and in vivo, and the protective effect of BHA against EC is mediated by increases in GST activity and GSH concentration. Expand
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
TLDR
Results provide evidence for the differential ability of test agents to modulate smoke-related biomarkers in the respiratory tract and other body compartments and highlight the potential advantages in combining chemopreventive agents working with distinctive mechanisms. Expand
Metabolism of 3-butene-1,2-diol in B6C3F1 mice. Evidence for involvement of alcohol dehydrogenase and cytochrome p450.
TLDR
The results suggest that BDD is extensively and rapidly metabolized in mice, and they provide evidence for the formation of reactive intermediates that could play a role in the toxicity of 1, 3-butadiene. Expand
Rapid effects of diesel exhaust particulate extracts on intracellular signaling in human endothelial cells.
TLDR
These data are the first characterization of rapid effects of DEPE in human EC and may indicate mechanisms for diesel exhaust in vascular function. Expand
Analysis of minocycline by high-performance liquid chromatography in tissue and serum.
TLDR
A sensitive and rapid reversed-phase high-performance liquid chromatography assay can be used to accurately determine serum and tissue minocycline concentrations and greatly facilitated the analysis of minocyCline while allowing for sensitivity. Expand
Oxidative metabolism of 7-methylbenz[a]anthracene, 12-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene by rat liver cytosol.
TLDR
The hypothesis that for most, if not all, unsubstituted polycyclic aromatic hydrocarbon carcinogens, the chemical or biochemical introduction of an alkyl group in the meso-anthracenic position(s) or L-region is a structural requirement for strong carcinogenic activity is supported. Expand
Bioalkylation of dibenz[a,b]anthracene in rat liver cytosol.
TLDR
The results suggest that unsubstituted carcinogenic hydrocarbons are preprocarcinogens that react with SAM in liver cytosol preparations, to form alkyl substituted procarcinogen, which are more potent than the corresponding preprocARCinogens. Expand
The use of a urine mutagenicity assay in the monitoring of environmental exposure to genotoxins.
TLDR
The results suggest the insufficient sensitivity of the TA98 tester strain to determinate low urinary level of mutagens and the use of the YG1041 tester strains increases the probability of detecting an effect of environmental exposure and seems to be applicable to biological monitoring. Expand
Rules of molecular geometry for predicting carcinogenic activity of unsubstituted polynuclear aromatic hydrocarbons.
TLDR
The present study reveals that there are structural determinants of carcinogenicity, and this makes it possible to include compounds of both aromatic types, in a consistent theory of aromatic hydrocarbon activation which incorporates alkyl substitution. Expand
Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction
TLDR
Serum total endothelin concentrations were significantly elevated in both myocardial infarct rats and sham-operated controls in response to PM exposure, which suggests that upregulation of theendothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity. Expand
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