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Protective effect of a synthetic anti‐oxidant on neuronal cell apoptosis resulting from experimental hypoxia re‐oxygenation injury
Oxidative stress is associated with the pathology of acute and chronic neurodegenerative disease. Cultured neuronal cells exposed to hypoxia‐reoxygenation (H/R) injury, as a model for stroke, yield aExpand
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Differential induction of glyoxylate cycle enzymes by stress as a marker for seedling vigor in sugar beet (Beta vulgaris)
Significant differences in seedling vigor exist among sugar beet (Beta vulgaris) hybrids; however, traditional approaches to breeding enhanced vigor have not proven effective. Seedling vigor is aExpand
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Mutations in the SPTLC1 protein cause mitochondrial structural abnormalities and endoplasmic reticulum stress in lymphoblasts.
Mutations in serine palmitoyltransferase long chain subunit 1 (SPTLC1) cause the typical length-dependent axonal degeneration hereditary sensory neuropathy type 1 (HSN1). Transmission electronExpand
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Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia–re-oxygenation injury
Oxidative stress is associated with the pathology of acute and chronic neurodegenerative disease. Cultured human neuronal cells exposed to experimental hypoxia-re-oxygenation (H/R) injury respondedExpand
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An initial top-down proteomic analysis of the standard cuprizone mouse model of multiple sclerosis
An initial proteomic analysis of the cuprizone mouse model to characterise the breadth of toxicity by assessing cortex, skeletal muscle, spleen and peripheral blood mononuclear cells. CuprizoneExpand
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Gecko-inspired chitosan adhesive for tissue repair
This study describes a simple one-step fabrication process of a chitosan film that has nanoscale pillars. The adhesive is laser-bonded to tissue and does not require pillar coating to enhance bondingExpand
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Increased lipid droplet accumulation associated with a peripheral sensory neuropathy
Hereditary sensory neuropathy type 1 (HSN-1) is an autosomal dominant neurodegenerative disease caused by missense mutations in the SPTLC1 gene. The SPTLC1 protein is part of the SPT enzyme which isExpand
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Optimal isolation of mitochondria for proteomic analyses.
Considering the key role of mitochondria in cellular (dys)functions, we compared a standard isolation protocol, followed by lysis in urea/detergent buffer, with a commercially available isolationExpand
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Proteomics of a conundrum: Thoughts on addressing the aetiology versus progression of multiple sclerosis
Currently in the field of multiple sclerosis (MS) research there is an ongoing debate concerning the cause of the disease. MS is widely considered to begin with an autoimmune dysregulation. TheExpand
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Transcript map of the candidate region for HSNI with cough and gastroesophageal reflux on chromosome 3p and exclusion of candidate genes
Dominantly inherited sensory neuropathy (HSNI) is a degenerative disorder of sensory neurons characterized predominantly by sensory loss with mild motor impairment. Recently our group identified aExpand
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